Candidiasis, Oral
Conditions
Keywords
Pediatric dentistry, Mouth, Edentulous
Brief summary
Little is known regarding the effectiveness of neonatal oral hygiene and its relationship to colonization by Candida spp. in edentulous oral cavities. Thus, the objective of this study is to evaluate whether the oral hygiene of edentulous infants favors colonization by Candida spp. Newborns with up to 48 hours of life will randomly allocated to two groups. The mothers will instructed to clean the oral cavity with gauze and mineral water three times a day, in the test group, and not to clean, in the control group.
Interventions
OTHERCleaning
Gauze and mineral water
OTHERNo oral cleaning
Absence of cleaning
Sponsors
Faculty Sao Leopoldo Mandic Campinas
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
No minimum to 2 Days
Healthy volunteers
Yes
Inclusion criteria
* A signed statement of informed consent * Newborns up to 48 hours of life * Exclusive breastfeeding * Edentulous oral cavity
Exclusion criteria
* Any feeding other than breastfeeding * Use of pacifier * Digit sucking * Systemic alterations
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from number of Candida spp CFU/mm3 | At baseline as well as once a month until the eruption of the first tooth (up to 14 months) | Non-stimulated saliva will be collected with the aid of a sterile swab (Absorve®) from all infants. The samples were incubated at 37°C and analyzed after 48 hours to quantify the colony forming units (CFU/mm3) |
Secondary
| Measure | Time frame |
|---|---|
| Mean of patient's birth weight in the test group as assessed by questionnaire | At baseline as well as once a month until the eruption of the first tooth (up to 14 months) |
| Number of males in the test group as assessed by questionnaire | At baseline as well as once a month until the eruption of the first tooth (up to 14 months) |
| Number of cesarean delivery in the test group as assessed by questionnaire | At baseline as well as once a month until the eruption of the first tooth (up to 14 months) |
| Mean of patient's gestational week in the test group as assessed by questionnaire | At baseline as well as once a month until the eruption of the first tooth (up to 14 months) |
| Mean of patient's birth length in the test group as assessed by questionnaire | At baseline as well as once a month until the eruption of the first tooth (up to 14 months) |
Countries
Brazil
Contacts
Primary ContactSandra Regina E. da Silva, PhD
Outcome results
None listed