Autoimmune Encephalitis
Conditions
Brief summary
Autoimmune encephalitis represents a group of rare and heterogeneous neurological disorders. Pathophysiological mechanisms in these diseases are still unknown. Recently, oculomotor and neurovisual disorders have been described. Cerebral areas and neuronal networks associated with these abnormalities are well described. The investigator proposes to study and describe such neuro-ophthalmological disorders in a prospective cohort of patients with a autoimmune encephalitis, to better understand the pathophysiological basis of this neurological condition.
Interventions
OTHERoculomotor movement recordings, neurovisual assessment
Each participant will have a neurovisual assessment and an oculomotor movement recording with an eye tracker (infra red cameras).
Sponsors
Hospices Civils de Lyon
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosis of autoimmune encephalitis * With or without pathological antibody * Aged from 18 to 70 years old * Able to understand the aims and methods of this project * Non opposed to the participation of this study
Exclusion criteria
* Other neurological, psychiatric or systemic conditions, which could induce neuro-ophthalmological signs Cognitive impairment, which is not linked to autoimmune encephalitis * Ophthalmological condition, which could modify the interpretation of neuro-ophthalmological data Inability to remain seated * Pregnancy or breast feeding * Adults under guardianship
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Percentage of patients presenting a neuro-ophthalmological abnormality. | Day 0 | A neuro-ophthalmological disorder is defined as an abnormality in the oculo-motor movement recording or/and the presence of a neurovisual impairment. |
| Percentage of patients presenting neuro-ophthalmological abnormality. | At 6 months if an abnormality is found | A neuro-ophthalmological disorder is defined as an abnormality in the oculo-motor movement recording or/and the presence of a neurovisual impairment. |
Countries
France
Outcome results
None listed