Chronic Obstructive Pulmonary Disease
Conditions
Keywords
atrial fibrillation, autonomic function, cardiopulmonary interaction
Brief summary
In the presented study, autonomic function as well as risk for atrial fibrillation will be assessed to characterize the relation between risk of atrial fibrillation and autonomic function.
Detailed description
Atrial fibrillation (AF) has been suggested as relevant comorbidity in patients with chronic obstructive pulmonary disease (COPD). The evaluation of the total atrial conduction time via tissue Doppler imaging (PA-TDI interval) can be used to identify patients with increased risk of new onset AF. Autonomic function can be assessed by different non invasive clinical investigations. The investigators hypothesise that PA-TDI interval is increased in acutely exacerbated COPD (AECOPD) compared within stable COPD and that increased PA-TDI is related to impairment of autonomic function. For this purpose, 25 patients with AECOPD and 25 patients with stable COPD were characterized by clinical characteristics, laboratory tests, lung function, electrocardiography, echocardiography and autonomic function.
Interventions
OTHERMeasurement of lung function, electrocardiography, echocardiography and autonomic function
Measurement of lung function, electrocardiography, echocardiography and autonomic function
Sponsors
Heinrich-Heine University, Duesseldorf
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
40 Years to 80 Years
Inclusion criteria
* patients with chronic obstructive pulmonary disease, exacerbated or stable between the age of 40-80 years with sinus rhythm who gave informed written consent
Exclusion criteria
* Inability to give written consent, acute myocardial infarction with ST-segment elevations in last 30 days, severe acute or chronic renal dysfunction, severe heart failure, atrial fibrillation, severe valve disease, severe hypotension, active malignant disease, active rheumatic disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| total atrial conduction time | Baseline | total atrial conduction time via tissue Doppler imaging (PA-TDI interval) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Baroreflex sensitivity | Baseline | For the assessment of autonomic function different test that characterize sympathetic or parasympathic function are performed. All tests for autonomic function are non invasive. |
| Chemoreflex sensitivity | Baseline | For the assessment of autonomic function different test that characterize sympathetic or parasympathic function are performed. All tests for autonomic function are non invasive. |
| Deep breathing test | Baseline | For the assessment of autonomic function different test that characterize sympathetic or parasympathic function are performed. All tests for autonomic function are non invasive. |
| Heart rate variability | Baseline | For the assessment of autonomic function different test that characterize sympathetic or parasympathic function are performed. All tests for autonomic function are non invasive. |
| Cold pressure test | Baseline | For the assessment of autonomic function different test that characterize sympathetic or parasympathic function are performed. All tests for autonomic function are non invasive. |
| Cold face test | Baseline | For the assessment of autonomic function different test that characterize sympathetic or parasympathic function are performed. All tests for autonomic function are non invasive. |
| Ewing test | Baseline | For the assessment of autonomic function different test that characterize sympathetic or parasympathic function are performed. All tests for autonomic function are non invasive. |
Countries
Germany
Outcome results
None listed