Impact of Congenital Heart Disease on Neurodevelopmental Outcome

Conditions

Heart Defects, Congenital

Keywords

Magnetic resonance imaging, Brain, Neuropsychology, Heart Defects, Congenital, Follow-Up Studies

Brief summary

The project aims toward clarifying the underlying mechanism and the long-term impact of congenital heart disease on neurodevelopment.

Detailed description

The project provides detailed information on the impact of congenital heart disease on neurodevelopmental outcome in adulthood. The study investigates if brain maturation and development, and the neurocognitive outcome is compromised in patients with atrial or ventricular septal defects more than 20 years after diagnosis and treatment. Data on brain morphology, brain tissue architecture, and resting-state function will be obtained by 3.0 Tesla MRI. Data on neurocognitive outcome will be obtained by a customized wide neuropsychological test battery. This study will clarify the extent of these patients' neurodevelopmental challenges and guide evaluate targeted interventions to alleviate potentially long-term effects.

Benjamin Asschenfeldt, Lars Evald, Camilla D. Salvig, Johan Heiberg, Leif Østergaard et al. (7 authors)

Journal of the American Heart Association2022-06-147 citations

10.1161/jaha.121.020915

Hyperactivity and Inattention in Young Patients Born With an Atrial Septal or Ventricular Septal Defect

Sara Hirani Lau-Jensen, Benjamin Asschenfeldt, Lars Evald, Vibeke E. Hjortdal

Frontiers in Pediatrics2021-12-0612 citations

10.3389/fped.2021.786638

Abnormal Left‐Hemispheric Sulcal Patterns in Adults With Simple Congenital Heart Defects Repaired in Childhood

Benjamin Asschenfeldt, Lars Evald, Hyuk Jin Yun, Johan Heiberg, Leif Østergaard et al. (9 authors)

Journal of the American Heart Association2021-03-2214 citations

10.1161/jaha.120.018580

Neuropsychological Status and Structural Brain Imaging in Adults With Simple Congenital Heart Defects Closed in Childhood

Benjamin Asschenfeldt, Lars Evald, Johan Heiberg, Camilla D. Salvig, Leif Østergaard et al. (8 authors)

Journal of the American Heart Association2020-05-1953 citations

10.1161/jaha.120.015843

Interventions

OTHERMagnetic Resonance Imaging

Magnetic Resonance Imaging (MRI) of the brain's macro- and microstructures. Furthermore, brain regional interactions and activity is examined with quantitative functional-MRI (fMRI)

OTHERNeuropsychological assessment

A special designed neuropsychological test battery of validated tests to assess function of cognitive domains

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 42 Years

Healthy volunteers

Yes

Inclusion criteria

* ICD codes DX Q21.0 (VSD) or DX Q21.1 (ASD), surgically repaired VSD or open ASD

Exclusion criteria

* lack of medical record, suffering from coronary artery disease or other congenital cardiac abnormalities, diagnosed syndromes, spontaneous closure of the atrial septum defect before inclusion-date, magnetic implants or non-MRI compatible foreign objects, pregnancy, lack of Danish language skills or suffering from severe lung disease

Design outcomes

Primary

Measure	Time frame	Description
Long-term impact of congenital heart disease on brain development	12 months	MRI analysis

Secondary

Measure	Time frame	Description
Long-term impact of congenital heart disease on neurocognitive outcome	12 months	Neuropsychological assessment

Countries

Denmark

Outcome results

None listed