Doppler Examination, Leiden Factor V Deficiency,Preeclampsia, Palental Pathology
Conditions
Brief summary
this summary studied the predictive values of factor V Leiden mutation , doppler indices , placental pathology to unfavorable fetal and maternal outcomes
Detailed description
leiden mutation is activated protein C resistance with hypercoagulable states and increased thrombotic risk. 99 % are heterozygous and 1 % is homozygous , very rare cases are psoudohomozygous with factor V deficiency. relation to this mutation was studied in severe preeclamptic patients. doppler indices of uterine arteries , increased pulsetility index or unilateral or bilateral uterine artery notch and placental pathology were studied.
Interventions
DIAGNOSTIC_TESTblood sample , doppler of uterine vessel and placenta
blood sample for factor V and doppler examination of uterine arteries , placenta pathology post partum
Sponsors
Cairo University
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
severe preeclampsia in 3rd trimester -
Exclusion criteria
Twin pregnancy. Fetal congenital anomalies. Diabetic patient, impaired renal function. Any medical disorders even that HTN. Any placental pathology,Autoimmune diseases. Women with uterine activity or clinical emergencies with maternal hemodynamic instability or an indication for immediate termination of pregnancy. \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| percentage of patients develop abruption placenta, intrauterine growth retardation or delivered premature | within 12 wks from diagnosis of severe preeclampsia | placental abruption, prematurity, IUGR |
| percentage of fetuses and neonates complicated with intrauterine fetal death or need admission to incubator | from diagnosis of severe preeclampsia till one week after delivery | IUFD, admission to neonatal IUC |
Outcome results
None listed