Effect of Genetic Polymorphism on the Occurrence of Post-Operative Atrial Fibrillation After CABG

Effect of Genetic Polymorphism on the Occurrence of Post-Operative Atrial Fibrillation After Coronory Artery Bypass Grafting (CABG) Surgery in Egyptian Patients Receiving Beta Blockers

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03871647

Enrollment

256

Registered

2019-03-12

Start date

2019-03-11

Completion date

2021-03-07

Last updated

2021-11-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial Fibrillation, Coronary Bypass Graft Surgery

Brief summary

Postoperative Atrial Fibrillation (POAF) is one of the most common complications following coronary artery bypass grafting (CABG) occurring to 20% - 40% of patients. It is associated with prolonged hospitalization, increased hospital costs, increased complications and mortality rate. Despite the use of Beta Blockers, approximately 20% of patients develop atrial fibrillation following CABG surgery, suggesting a role for polymorphism in the genes The aim of the present study is to determine the minor allele frequency of some of the genes that affect the beta blockers' response and to determine the association between polymorphism in these genes and the occurrence of postoperative atrial fibrillation after coronary artery bypass grafting in Egyptian patients receiving perioperative beta blockers.

Interventions

DRUGBeta blocker

perioperative beta blockers

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 100 Years

Healthy volunteers

Inclusion criteria

1. Age above 18 years. 2. Candidates for CABG surgery without a concurrent valve surgery. 3. Patients receiving perioperative beta blockers before new onset of postoperative AF.

Exclusion criteria

1. Patients who have either persistent or permanent AF, atrial flutter or atrial tachycardia on ECG obtained on the day of the operation. 2. Serum creatinine \>2 mg/dL before the surgery. 3. Uncontrolled thyroid disease. 4. Recent treatment with amiodarone before the occurrence of POAF

Design outcomes

Primary

Measure	Time frame	Description
Occurrence of Atrial fibrillation	within 6 days after the operation	Atrial fibrillation based on postoperative electrocardiogram. AF diagnostic criteria will include absence of discrete P waves, the RR intervals follow unrepetitive form and the ranges of ventricular rate usually between 90 and 170 beats/min.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 13, 2026