Field Paramedic Application of Sepsis Triage

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03870789

Acronym

FAST

Enrollment

400

Registered

2019-03-12

Start date

2016-12-11

Completion date

2019-12-31

Last updated

2019-03-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis

Keywords

sepsis, septic shock, early warning scores, infecion

Brief summary

Given the implementation of the Hamilton Early Warning Score (HEWS) and the use of capnography by paramedics, this study will involve a large multi-site retrospective evaluation (before vs after implementation) of the HEWS score and comparison of the HEWS to systemic inflammatory response syndrome (SIRS), quick Sepsis Related Organ failure Assessment (qSOFA) and Modified Early Warning Score (MEWS) when applied retrospectively for the identification of sepsis in the prehospital setting.

Detailed description

1. To determine the accuracy of the HEWS score, compared to qSOFA, and SIRS for early sepsis recognition when used in the prehospital setting by paramedics for the identification of patients with sepsis or suspected sepsis. 2. To evaluate the addition of ETCO2 values to predict mortality in patients who screen positive for sepsis. 3. To identify the before and after healthcare outcomes of a prehospital sepsis alert program.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Any patient to which paramedics apply the Hamilton Early Warning Score or patients who arrive to the Emergency Department (ED) by ambulance without a pre-alert and meet the definition of sepsis in the ED will also be included, and patient is ≥ 18 years

Exclusion criteria

Patient is an inter-facility transfer, or patients with absent vital signs are absent, or death before blood can be drawn in the Emergency Department, or the patient fits the criteria for another prehospital alert (ST-elevation myocardial infarction, cerebrovascular vascular accident, or trauma)

Design outcomes

Primary

Measure	Time frame	Description
Accuracy of HEWS	1 year	To determine the accuracy of the HEWS score, compared to qSOFA, and SIRS for early sepsis recognition when used in the prehospital setting by paramedics for the identification of patients with sepsis or suspected sepsis.

Secondary

Measure	Time frame	Description
Evaluate the addtion of end-tidal carbon dioxide (ETCO2) values	1 year	To evaluate the addition of ETCO2 values to predict mortality in patients who screen positive for sepsis.
Evaluate sepsis alert program	2 years	To identify the before and after healthcare outcomes of a prehospital sepsis alert program.

Countries

Canada

Contacts

Primary ContactNatasha Clayton, CRA, RA

clayton@mcmaster.ca905-521-2100

Outcome results