Aerobic Exercise Intervention or Home Exercise, Diabetes and Healthy Control, FTO Gene Expression, Pre-training and Post-training
Conditions
Keywords
diabetes, muscle quality, aerobic exercise, FTO gene
Brief summary
The aim of the first year of this three-year plan is to analyze and compare the muscle quality of lower limb muscle (microcirculation, muscle performance and mechanical characteristics) and maximal aerobic exercise capacity in treadmill exercise tests for diabetic and non-diabetic cases. The hypotheses are:1) the muscle quality of lower limb muscle and maximal aerobic exercise capacity are different between participate with diabetic and non-diabetic, 2) the effect of the three-month aerobic exercise intervention or home exercise on the characteristics of the muscle quality are different , and 3) intrinsic factors (such as age, BMI, and HDL) and characteristics of specific FTO genes are influenced the training outcomes.
Detailed description
Participants with diabetes will attend an 12-week aerobic exercise intervention or home exercise if the exercise test result of the maximum rate of oxygen consumption is fair or poor. Assessments will be taken before and after the training program, which including muscle strength, stiffness, quality, microcirculation and exercise capacity. Comparisons between the pre-training and post-training condition will be made for each groups. And the assessments also compare with the healthy control group.
Interventions
BEHAVIORALsupervised aerobic exercise or home-based aerobic exercise
The aerobic exercise and home exercise programs are consisted of 50 minutes per time, 3 times per weeks and totally 3 months. The aerobic exercise group will perform the exercise program under one physical therapy and one aerobic dance teacher supervised. The home exercise group will do the exercise program based on ACSM's aerobic exercise recommend, and will used the home exercise record form to make sure their cooperation.
Sponsors
National Taiwan University Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
his study is going to recruit subjects with and without type 2 diabetes and age between 30 and 70 years old. This study will be focused on the effects of diabetes on maximum aerobic exercise intensity (VO2max) and muscle quality including microcirculation (by NIRS), mechanical properties (by elastography) and isometric strength in different age groups, and observe whether these results are related to the clinically relevant findings of diabetes. This study will recruit qualified diabetic subjects according to their results of maximal aerobic exercise capacity (VO2max) and assign them into two groups; aerobic exercise or home exercise intervention.
Eligibility
Sex/Gender
ALL
Age
30 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Diabetes group: 1) Age between 30-70 years of old, 2) type 2 diabetes. * Healthy control group: 1) Age between 30-70 years of old, 2) without diabetes
Exclusion criteria
* history of moderate-severe somatic or autonomic neuropathy, cardiovascular disease, preproliferative or proliferative retinopathy, and chronic renal failure * unable to perform the programs or assessments * other systematic diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| maximum rate of oxygen consumption | Baseline | Bruce treadmill protocol was used in the maximal exercise testing, maximum rate of oxygen consumption record as ml/kg/min |
| index of muscle stiffness | Change from Baseline muscle quality at 3 months | elastography was used, units on kPa |
| muscle strength of knee extensor and plantarflexor | Change from Baseline functional performance at 3 months | Dynamometer was used to measure muscle strength, units on kilograms |
| Relative sliding of muscles | Change from Baseline muscle quality at 3 months | B mode sonography was used, units on mm/s |
| muscle microcirculation | Change from Baseline muscle quality at 3 months | Near-infrared spectroscopy was used to measure oxygen saturation on muscle, units on percentage |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| characteristics of specific FTO genes | Baseline | rs9939609 SNP analysis, record as TT or TA or AA type |
| physical activity level | Change from Baseline functional performance at 3 months | self report the ability of walking one-fourth of a mile, record as degree of difficulty: none, some difficulty, much difficulty, inability |
| BMI | Change from Baseline functional performance at 3 months | weight and height will be combined to report BMI in kg/m\^2 |
| blood glucose level | Change from Baseline functional performance at 3 months | Hemoglobin A1c (HbA1c), unit on percentage |
| blood cholesterol | Change from Baseline functional performance at 3 months | total cholesterol, units on mg/dL |
Countries
Taiwan
Outcome results
None listed