Anesthesia
Conditions
Brief summary
The purpose of this study is to compare the addition of dexmedetomidine to bupivacaine versus bupivacaine only in anterior QLblock(transincisional) , where the local anesthetic will be applied before wound closure at the end of surgery through the wound . in combination with general anesthesia in elective open renal surgery with regard to Postoperative pain control,hemodynamic stability, and adverse effects.
Interventions
patients will receive combined general anesthesia and Quadratuslumborum block( transincisional ie before wound closure)with 19 mL of bupivacaine 0.20%plus 1 mic/kg of dexmedetomidine, total volume 20 ml
DRUGBupivacaine
patients will receive combined general anesthesia and quadratus lumborum block (transincisional) with 20 ml of bupivacaine 0.20% .
Sponsors
Ain Shams University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* physical status American Society of Anesthesiologist (ASA) I or II
Exclusion criteria
* Patients refusal * A body mass index (BMI) \>30 kg/m2 * ASA physical status \>II * major illnesses (e.g., cardiac, respiratory, renal, hepatic or neurological) * Coagulation abnormalities * Infection at the injection site * Allergy or contraindications to the drugs used in the study * History of drug addiction or alcohol abuse * A psychiatric illness, or mental retardation interfering with the evaluation of pain scores or PCA programs .
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| First time to analgesic requirement | 1st 24 hour postoperatively | After extubation, an intravenous patient - controlled system, will be connected to the patient (Accufuser plus 100 ml) will be prepared with 60 ml isotonic saline containing 60 mg morphine , it will be programmed to give 0.5 ml bolus dose with lockout interval of 8 minutes. Time to first bolus will be recorded considering extubation time is the zero time |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| the secondary outcomes will be the total opioid consumption postoperatively | 1st 24 hour | PCA will prepared with 60 mL of normal saline containing 60 mg of morphine, and the system will be programmed to give a 0.5 mL bolus dose with a lockout interval of 8 min. |
Countries
Egypt
Outcome results
None listed