Liver Cirrhoses
Conditions
Keywords
MRI, cirrhosis
Brief summary
This study aims to assess the alteration of portal and splanchnic flow using MRI after liver transplantation in patients with splenomegaly or splenic varix.
Interventions
DIAGNOSTIC_TESTLiver MRI
Liver MRI including 4D flow sequence is performed twice in liver transplantation recipients, before and 1 month-after transplantation. In donor candidates, liver MRI including 4D flow sequence is performed twice in 1-3 weeks to assess repeatability of the technique.
Sponsors
Seoul National University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* older than 18 years * And signed informed consent * And planned either a) liver transplantation as a recipient; or b) liver transplantation as a donor
Exclusion criteria
* any absolute/relative contraindication of contrast-enhanced MRI
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Portal flow | in a month after 2nd MRI | portal flow measured with MRI (4D flow sequence) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| SMV flow | in a month after 2nd MRI | superior mesenteric vein (SMV) flow measured with MRI (4D flow sequence) |
| Splenic vein flow | in a month after 2nd MRI | splenic vein flow measured with MRI (4D flow sequence) |
| splenic varix flow | in a month after 2nd MRI | splenic varix flow measured with MRI (4D flow sequence) only in liver recipients |
Countries
South Korea
Outcome results
None listed