Osteopenia
Conditions
Brief summary
Determine the severity and time course (natural history) of disuse osteopenia that occurs in the lower extremity(ies) and lumbar spine of patients sustaining lower extremity injuries that require the patient to maintain restricted weight bearing status (12 weeks) following the surgical fixation of the patient's injuries. The investigators hypothesize that there will be a significant decrease in the bone mineral density in the lower limbs of patients undergoing restricted weight bearing for peri-articular injuries of the lower extremity. This loss of bone mineral density is often prolonged in its duration and may lower subsequent fracture threshold and prolong the time to recovery and return to activities.
Detailed description
It is well documented that restricted weight bearing even for relatively short periods (12 weeks) associated with the surgical treatment of peri-articular injuries of the lower extremity (ie acetabulum, distal femur, tibial plateau, pilon, talus, calcaneus) can lead to a measurable decrease in bone density in the injured limb. Furthermore, this osteopenia can persist for extended periods of time - much longer than the original period of restricted weight bearing. This relative osteopenia can delay recovery from injury, lower fracture threshold for subsequent injury and potentially delay return to active duty in the case of a wounded warrior. There exists a significant body of research in the modulation of the osteopenia associated with restricted weight bearing as it pertains to long term space flight (microgravity).
Interventions
DIAGNOSTIC_TESTdual energy x-ray absorptiometry
DXA scan
Sponsors
Milton S. Hershey Medical Center
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
1. Age 18-70 at time of injury 2. Previously normal community ambulator (without ambulatory aid) prior to injury
Exclusion criteria
1. Presence of a total or hemi hip prosthesis in the injured extremity 2. Presence of lumbar fusion L1-L4 3. Previous ipsilateral lower extremity trauma 4. History of medical treatment for known osteoporosis (Calcium and Vitamin D supplementation alone is NOT an
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Determine the natural history of disuse osteopenia following restricted weight bearing from a lower extremity articular injury | 36 months | Hip bone mineral density (DXA) of control and injured limb will be measured following weight bearing restrictions as part of treatment of lower limb articular injury and again following resumption of weight bearing after healing of the injury. |
Countries
United States
Outcome results
None listed