Erectile Dysfunction
Conditions
Keywords
Erectile dysfunction, Vitamin-D, Hypogonadism, Endothelial Dysfunction, Nitric Oxide
Brief summary
In present study, we aimed to investigate the association between erectile function severity of serum 25-Hydroxyvitamin-D and cut-off level to treat men with erectile dysfunction.
Detailed description
Investigators retrospectively analysed 130 patients admitted to the complaint of erectile dysfunction between aged between 18-80 years old from June 2017 to October 2018 at Cigli Region Training Hospital Urology department and Recep Tayyip Erdogan University Urology Department. International index of erectile function-5 (IIEF-5) Turkish validated short form quesstionaire was performed to all patients. Antropometric characteristics including weight, height, waist circumference, body mass index (BMI) and presence of comorbide diseases were recorded. After detailed history and physical examination performed all patients, overnight fasting in the morning between 08:00-10:00, blood samples from antecubital vein were performed and serum glucose, lipid profile, follicular stimulating hormon (FSH), Luteinizing hormone (LH), total testosterone, prolactin, estradiol, 25(OH)D level were analysed. Presence of uncontrolled diabetes mellitus, uncontrolled hypertension, uncontrolled lipid metabolism disorders, neurological diseases, heamatological diseases, urinary tract infection, malignencies, chronic kidney failure, metabolic syndrome, psychiatric diseases and/or medical treatment, smoking, history of pelvic surgery, cardiac surgery and pelvic radiotherapy were accepted as exclusion criterias from the study. After IIEF-5 score adjust as 21 point, ROC analyse was used to calculate the cut-off value of 25(OH)D and level of 27.32 ng/mL was calculated as cut-off value. Patients were divided into two group according to 27.32 ng/mL level as a cut off value. Serum 25(OH)D level was lower than 27.32 ng/mL in group 1 (severe and moderate symptomatic group) and higher than 27.32 ng/mL in group 2 (mild symptomatic group).
Interventions
OTHER25-Hydroxy vitamin D
27.32 is calculated as a cut fo level for 25 hydroxy vitamin D deficiency
Sponsors
Recep Tayyip Erdogan University Training and Research Hospital
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
MALE
Age
18 Years to 80 Years
Inclusion criteria
* presence of erectile dysfunction
Exclusion criteria
* Presence of uncontrolled diabetes mellitus, * Presence of uncontrolled hypertension, * Presence of uncontrolled lipid metabolism disorders, * Presence of neurological diseases, * Presence of heamatological diseases, * Urinary tract infection, * Diagnosis of any malignencies, * Chronic kidney failure, * Presence of metabolic syndrome, * Presence of psychiatric diseases and/or medical treatment, * Smoking, * History of pelvic surgery, cardiac surgery and pelvic radiotherapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Laboratory results | 1 year | Serum 25 Hydroxy vitamin D levels (ng/mL), group 1 include patients with serum 25 hydroxy vitamin D levels higher than 27.32 ng/ml and Group 2 include patients with serum 25 hydroxy vitamin D levels lower than 27.32 ng/mL |
| Clinical results | 1 year | IIEF-5 quesstionaire score (0-15 point is severe erectile dysfunction, 16-21 point is moderate erectile dysfunction and \>21 point is mild erectile dysfunction) |
Countries
Turkey (Türkiye)
Outcome results
None listed