Idiopathic Intracranial Hypertension
Conditions
Keywords
End-Tidal Carbon Dioxide, Venous Sinus Stenting, Venous Sinus Caliber and Pressures
Brief summary
The purpose of this study is to further elaborate the role of both arterial blood pressure and end-tidal carbon dioxide concentration on measured venous pressures.
Detailed description
To prospectively evaluate the effect of changes in end-tidal carbon dioxide and arterial blood pressure on venous sinus pressure measurements in patients undergoing venous sinus stenting under general anesthesia. Venous sinus pressure measurements will increase with increases in both arterial blood pressure and end-tidal carbon dioxide concentrations.
Interventions
PROCEDUREVenous Sinus Stenting
Venous sinus stenting is performed under general anesthesia. Patients are loaded with aspirin and clopidogrel before the procedure. After induction, the right femoral vein is accessed and an 8 F sheath is placed. Intravenous heparin is administered. A 0.070-0.088 guide catheter is navigated into the ipsilateral jugular vein near the jugular bulb. Pre-stenting manometry is performed in every patient. To do so, a Renegade Hi-Flo microcatheter is navigated into the superior sagittal sinus and then used to measure ipsilateral venous pressures across the site of outflow obstruction (this will be the time point where the study intervention will be performed).
OTHERAdjustment to end-tidal carbon dioxide concentrations ( 38-40 mmHg range)
End-tidal carbon dioxide concentrations will be adjusted to fall in the End-tidal carbon dioxide concentrations will be adjusted to fall in the 38-40 mmHg range
OTHERAdjustment to Mean Arterial Pressure (100-110 mmHg range)
Mean arterial pressure will be adjusted to fall in the 100-110 mmHg range
OTHERAdjustment to Mean Arterial Pressure (60-80 mmHg range)
Mean arterial pressure will be adjusted to fall in the 60-80 mmHg range
OTHERAdjustment to end-tidal carbon dioxide concentrations (24-26 mmHg range)
End-tidal carbon dioxide concentrations will be adjusted to fall in the 24-26 mmHg range
Sponsors
Wake Forest University Health Sciences
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adults determined to be candidates for venous sinus stenting
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Venous Sinus Pressures | Baseline |
Secondary
| Measure | Time frame |
|---|---|
| Venous Sinus Diameter | Baseline |
Countries
United States
Outcome results
None listed