Ankylosing Spondylitis, BMD, Osteoporosis
Conditions
Brief summary
Our clinical study aimed to evaluate the prevalence of osteoporosis (OP) in patients with ankylosing spondylitis (AS) and to investigate the relationship between clinical, disease activity, physical function and disease duration, and bone mineral density (BMD).
Detailed description
In this cross-sectional study, patients who were admitted to the rheumatology clinic between 18 and 65 years of age and diagnosed as AS according to the modified New York diagnostic criteria were included Patients group was divided two part as patients with (group 1)and without (group 2) osteoporosis. The patient's global rating scale is a self-assessed scale of the patient with a grade of 10 (1: very bad, 5: moderate, 10: very good). To assess the disease activity, Bath ankylosing spondylitis disease index (BASDAI) and Bath ankylosing spondylitis functional index (BASFI) were evaluated. BASDAI is a self-assessment scale used to determine disease activity in patients with AS. Schober measurement was used to evaluate lumbar mobility of the patients. Chest expansions were measured in all patients. Body mass index (BMI) was calculated as kg/height m2. Erythrocyte sedimentation rate (ESH mm / h), C-reactive protein (CRP mg / l) levels were measured in all patients. BMD measurements were made by using dual-energy x-ray absorptiometry (DEXA) and lumbar vertebra (L1-4) and left femur (femoral neck and total) regions. DEXA measurements (GE / LUNAR DPX PRO) were performed and the results were recorded using standard T score. Bone mineral densities of patients were based on the World Health Organization (WHO) classification of a T score between -1 and -2.5 for osteopenia; and a score of -2.5 for osteoporosis.
Interventions
None listed
Sponsors
Bezmialem Vakif University
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Patients diagnosed as AS according to the modified New York diagnostic criteria were included
Exclusion criteria
* Patients previously diagnosed with OP, * Patients previously treated with OP, * Patients with bone fractures previously associated with OP, * Those using drugs that affect bone metabolism, metabolic bone diseases (Paget's -disease, osteomalacia, hyperparathyroidism), * Diabetes mellitus, * Hypothyroidism, hyperthyroidism, * Patients with kidney, liver and intestinal diseases, * Those using corticosteroids
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Bath ankylosing spondylitis disease index (BASDAI) | up to 6 month | BASDAI, is a widely used patient-reported outcome to measure disease activity in AS. It comprises only six questions (Box 5.1). The answers to these questions are scored on a 0-10 NRS, which are anchored by 0 (none) to 10 (very severe). The BASDAI sum score is calculated by the sum of questions 1-4 plus mean of questions 5 and 6, the total then divided by 5. The sum score ranges from 0 to 10, higher values indicate more active disease. |
| Bath ankylosing spondylitis functional index (BASFI) | up to 6 month | Bath Ankylosing Spondylitis Functional Index (BASFI): this is the most frequently used tool to asses function in AS. It contains 10 questions on activities of daily living, which are scored with a rating scale from 0 (no functional impairments) to 10 (maximal impairment). The sum score ranges from 0 to 10, with higher values indicating worse functioning. |
Countries
Turkey (Türkiye)
Outcome results
None listed