Hepatitis B Infection
Conditions
Brief summary
China is a highly prevalent area of hepatitis B virus（HBV） infection, with at least 75 million hepatitis B virus carriers, and 80% of primary hepatocellular carcinoma (HCC) is associated with chronic hepatitis B virus infection. Liver transplantation is currently the preferred method for end-stage liver disease such as biliary atresia and cirrhosis in children. In recent years, children's liver transplantation has developed rapidly and the number of developments has increased significantly. If there is chronic hepatitis B virus infection in the donor liver, it may cause HBV transmission, or the patient may have a low-load occult hepatitis B virus infection, and after immunosuppressive treatment, it may lead to hepatitis B virus infection after surgery.
Interventions
None listed
Sponsors
Qiu Li
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Patients with end-stage liver disease who require liver transplantation
Exclusion criteria
* Children without liver transplantation refer to children; * Children who are unwilling to participate;
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The rate of occult hepatitis b virus infection | 3-5 years | Clinical follow-up testing for occult HBV infection after liver transplantation in children |
| The rate of overt hepatitis b virus infection | 3-5 years | Clinical follow-up testing for overt HBV infection after liver transplantation in children |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The levels and changes of anti-HBs after liver transplantation | 3-5 years | Clinical follow-up testing for HBV seromarkers after liver transplantation in children |
Countries
China
Contacts
Primary ContactYao Zhao
Outcome results
None listed