Correlation Study Between Clinical Phenotype and Pathology of Type 2 Diabetic Nephropathy

Conditions

Diabetic Kidney Disease

Keywords

Diabetic kidney disease (DKD), Diabetic nephropathy（DN), non-diabetic renal diseases（ NDRD), Clinical-pathological correlations, differential diagnosis

Brief summary

With the rapid increase of diabetic nephropathy worldwide, type 2 diabetes mellitus(DM) is the leading cause of end-stage renal disease(ESRD). Pathological types of diabetic kidney disease(DKD) could be mainly divided into diabetic nephropathy（DN）and non-diabetic renal diseases（NDRD）. There are no accurate renal biopsy indications and standardized operation procedures for type 2 diabetic nephropathy. The clinical stages of type 2 diabetic nephropathy still referred to the Mogensen stage of type 1 diabetic nephropathy. Thus, our study aim to clarify the differences in clinical phenotype between type 2 DN and type 2 NDRD, analysis the correlation between clinical and pathological features, and offer the criteria for clinical staging and prognosis.

Wang Q, Zhou S, Niu Y, Li C, Lyu Q, Chen P, Zhang X, Xie L, Shen W, Wang Y, Cao X, Cai G, Chen X, Wang H, Dong Z.

2026-04-20

10.1186/s13244-026-02274-9

A multimodal transformer system for noninvasive diabetic nephropathy diagnosis via retinal imaging.

Dong Z, Wang X, Pan S, Weng T, Chen X, Jiang S, Li Y, Wang Z, Cao X, Wang Q, Chen P, Jiang L, Cai G, Zhang L, Wang Y, Yang J, He Y, Lin H, Wu J, Tang L, Zhou J, Li S, Li Z, Fu Y, Yu X, Geng Y, Zhang Y, Wang L, Xu M, Chen X.

2025-01-248 citations

10.1038/s41746-024-01393-1

The relationship between diabetic retinopathy and diabetic nephropathy in type 2 diabetes

Qian Wang, Haimei Cheng, Shuangshuang Jiang, Li Zhang, Xiaomin Liu et al. (14 authors)

Frontiers in Endocrinology2024-01-2629 citations

10.3389/fendo.2024.1292412

New Diagnostic Model for the Differentiation of Diabetic Nephropathy From Non-Diabetic Nephropathy in Chinese Patients

Weiguang Zhang, Xiaomin Liu, Zheyi Dong, Qian Wang, ZhiYong Pei et al. (13 authors)

Frontiers in Endocrinology2022-06-3042 citations

10.3389/fendo.2022.913021

Evaluation of Renal Impairment in Patients with Diabetic Kidney Disease by Integrated Chinese and Western Medicine.

Qu YL, Dong ZY, Cheng HM, Liu Q, Wang Q, Yang HT, Mao YH, Li JJ, Liu HF, Geng YQ, Huang W, Liu WH, Xie HD, Peng F, Li S, Jiang SS, Li WZ, Duan SW, Feng Z, Zhang WG, Liu YN, Tian JZ, Chen XM.

2022-06-091 citations

10.1007/s11655-022-3520-0

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* Age≥18, male or female * Clinical diagnosed as type 2 diabetes mellitus * The presence of renal impairment including: microalbuminuria or overt proteinuria or renal insufficiency * The renal biopsy was performed with complete renal pathological diagnosis * Obtaining the signed informed consent from patients

Exclusion criteria

* The history of the disease was not complete * Clinical diagnosed as other secondary renal diseases * Patients with hereditary kidney disease * Autoimmune diseases * Patients with malignant tumor were expected to survive less than 6 months * Pregnancy and lactation

Design outcomes

Primary

Measure	Time frame	Description
change in eGFR and urine protein from baseline	24months	eGFR is calculated using the CKD-EPI formula, involving gender, age, and serum creatinine.

Countries

China

Contacts

Primary ContactXiangmei Chen, MD.&Ph.D

xmchen301@126.com+86 010 66935462

Backup ContactZheyi Dong, MD.&Ph.D

shengdai26@163.com+86 010 66935462

Outcome results