Atypical Benign Partial Epilepsy (ABPE), Benign Epilepsy With Centro Temporal Spikes (BECTS), Epileptic Encephalopathy With Continuous Spike and Waves During Sleep (ECSWS)
Conditions
Keywords
Memory consolidation, Epilepsy, Childhood, Benign epilepsy with centro temporal spikes (BECTS), Epileptic encephalopathy with continuous spike and waves during sleep (ECSWS)
Brief summary
Age related focal epilepsies in children encompasses, according to the ILAE criteria, benign epilepsy with centro temporal spikes (BECTS), atypical benign partial epilepsy (ABPE) and epileptic encephalopathy with continuous spike and waves during sleep (ECSWS). These non structural epilepsies are associated with interictal sleep spike and waves activated by sleep. Moreover, high prevalence of learning disorders occur in children with age related epilepsies. A correlation is suspected between learning disorders and sleep activation of spike and waves. The investigators suppose that learning dysfunction is linked to loss of information during sleep of epileptic children, unlike for control patients. As sleep allows memory consolidation of words learned during wakefulness, an epileptic activity during sleep may disrupt this consolidation, leading to a loss of information. Hypothesis: the investigators hypothesize a disruption of memory consolidation after one night in children affected with ABPE and ECSWS (severe group) compared to memory consolidation in children affected with BECTS (benign group), and control group. Primary purpose: To demonstrate that the deficit of delayed recall in 15 word learning test after one night is higher for the severe group, compared to the benign group and the control group. Secondary purposes: * to study the evolution over time of memory consolidation * to evaluate the correlation of the deficit of delayed recall with executive dysfunction, clinical factors of epilepsy, neurophysiological factors of epilepsy, and sleep architecture
Interventions
BEHAVIORALNeuropsychological testing
memory, executive testing, behaviour questionnaire, visual attention,
BEHAVIORALNeuropsychological procedure
Rey auditory verbal learning test, Delayed recall : 1h, 5h, 24h (after one night sleep)
OTHERVideo EEG and polysomnography
Video EEG : 10 electrodes + 3 electrodes for PSG 2h wake EEG Whole night EEG
Sponsors
University Hospital, Strasbourg, France
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
6 Years to 13 Years
Healthy volunteers
No
Inclusion criteria
Principal: * normal psychomotor development * informed consent signed by both parents and subject if able * affiliated to social security regimen Specific Patients from severe and benign groups: * focal age related epilepsy: BECTS, ABPE, ECSWS (ILAE criteria) * children hospitalized for their follow-up * normal neuroimaging Control group -children hospitalized for a non neurologic disease
Exclusion criteria
Principal: Psychiatric trouble (DSM V) Sensorial trouble without correction Poor command of French language Minor under care Specific Patients from severe and benign groups: * degenerative disease * abnormal neuroimaging * mental deficiency Control group * neurologic trouble * abnormal sleep EEG * intellectual deficiency
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| memory lapse rate at 24 hours in the severe group, the benign group and the control group. (memory lapse rate: rate of non recalled words number, during the delayed recall phase of the test, related to the maximal number of words recalled | 24 hours |
Secondary
| Measure | Time frame |
|---|---|
| memory lapse rate for each group | at 1 hour, 5 hours, 24 hours |
| Correlation of memory lapse rate with Executive functioning tests scores | at 1 hour, 5 hours, 24 hours |
| Correlation of memory lapse rate with age of onset, epilepsy phase, treatment | at 1 hour, 5 hours, 24 hours |
| Correlation of memory lapse rate with EEG severity scale, atypical criteria, EEG focus localization, sleep discharges frequency | at 1 hour, 5 hours, 24 hours |
| Correlation of memory lapse rate with number and organization of sleep cycles | at 1 hour, 5 hours, 24 hours |
Countries
France
Contacts
Primary ContactAnne DE SAINT MARTIN, MD
Backup ContactLucille SCHNEIDER
Outcome results
None listed