Combination Trial of Intravenous Paracetamol - Morphine for Treating Acute Renal Colic in Emergency Setting: An Optimum Treatment

Paracetamol Plus Morphine in ED

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03865004

Enrollment

136

Registered

2019-03-06

Start date

2015-10-17

Completion date

2018-10-17

Last updated

2019-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Renal Colic

Brief summary

This randomized, placebo-controlled trial evaluated the analgesic efficacy and safety of intravenous morphine-paracetamol combination and morphine-dexketoprofen combination morphine for the optimum treatment of renal colic. Combination of IV morphine and paracetamol is as effective and rapid as combination of IV Morphine and IV dexketoprophen for optimum treating of renal colic.

Interventions

DRUGParacetamol+Morphine

1gr paracetamol plus 0.1 mg/kg morphine were performed simultanously

DRUGDexketoprofen plus Morphine

Intravenous 75 mg Dexketoprofen plus 0,1 mg/kg morphine were performed simultanously

DRUGPlacebo plus Morphine

100 cc NaCl plus 0.1 mg/kg morphine were performed simultanously

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 55 Years

Healthy volunteers

Inclusion criteria

Renal colic patients -

Exclusion criteria

Not renal colic patients \-

Design outcomes

Primary

Measure	Time frame
pain reductions in VAS scores during the 60th and 90th minutes	60 minutes

Secondary

Measure	Time frame
Need for rescue analgesic	30 minutes

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026