Brain Death
Conditions
Keywords
Brain death, Oxygen metabolism, Near infrared spectroscopy
Brief summary
This study aims to evaluate brain death with optical probes. The changes of hemodynamic parameters including oxyhemoglobin (HbO2) and deoxyhemoglobin (Hb) were detected by near infrared spectroscopy probes attached on the forehead of patients. A multiple-phase protocol at varied fraction of inspired O2 were utilized during the assessment.
Detailed description
Brain death is an irreversible loss of all brain functions, and the assessment is crucial for organ supply for transplantation. The noninvasive, sensitive, universally available and timely ancillary method to assess brain death has not been established. This study aims to evaluate brain death with optical probes. The changes of hemodynamic parameters including oxyhemoglobin (HbO2) and deoxyhemoglobin (Hb) were detected by near infrared spectroscopy probes attached on the forehead of patients. A multiple-phase protocol at varied fraction of inspired O2 were utilized during the assessment. The concentration changes ratios of oxyhemoglobin to deoxyhemoglobin (Δ\[HbO2\]/Δ\[Hb\]) in the cerebral cortex of brain-dead patients were significantly higher than those of healthy subjects.
Interventions
The protocol consisted of 1-hour resting, 3-minute baseline measurement, half-hour measurement at 60% FIO2 (phase I, high oxygen), half-hour measurement at 40% FIO2 (phase II, low oxygen) and half-hour measurement at 60% FIO2 (phase III, high oxygen).
The protocol consisted of 1-hour resting, 3-minute baseline measurement, half-hour measurement at 40% FIO2 (phase I, low oxygen), half-hour measurement at 60% FIO2 (phase II, high oxygen) and half-hour measurement at 40% FIO2 (phase III, low oxygen).
DEVICEOptical monitor for hemodynamic parameter.
Near infrared spectroscopy probes of tow wavelengths were attached on the subjects' foreheat to detect the changes of hemodynamic parameters.
Sponsors
Chinese Academy of Medical Sciences
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients who have had brain death or serious brain trauma. * Healthy people who are interested in optical assessment of hemodynamic parameters
Exclusion criteria
* Patients who are in pregnancy or have plan to conception. * Patients who have vertebra surgery or have plan of surgery. * Patients who are inappropriate to join this trial judged by the radiologists or specialists. * AIDS, Active Hepatitis, Tuberculosis, Syphilis * Patients who regularly take anticoagulants, antiplatelet drugs
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Δ[HbO2] | 1 day during the whole experiment | The changes of oxyhemoglobin concentrations in prefrontal cortex. |
| Δ[Hb] | 1 day during the whole experiment | The changes of deoxyhemoglobin concentrations in prefrontal cortex. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Heart rate | 1 day during the whole experiment | Heart rate of patient recorded by bed-side physiological monitor. |
| Blood pressure | 1 day during the whole experiment | Blood pressure of patient recorded by bed-side physiological monitor. |
Countries
China
Outcome results
None listed