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Analysis of the Variation of the Retinal Vascularization After a Prolonged Effort

Analysis of the Variation of the Retinal Vascularization After a Prolonged Effort

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03864380
Acronym
MARETINE
Enrollment
29
Registered
2019-03-06
Start date
2019-03-15
Completion date
2019-05-06
Last updated
2019-05-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Retinal Vascular Disorder, Sport Injury

Keywords

Retinal Vascularization, Intense effort, OCT-A

Brief summary

The cardiovascular parameters of prolonged physical exercice have been studied, but very little data is available about the retinal vascularization. The eye allows in vivo visualization of micro-vascularisation and is considered as an excellent marker of general vascular condition. The marathon is an intense and prolonged exercise (running 42.195 km) in aerobic environment. Thus the investigators propose to study the vascular parameters of the retina, before and after this physical exercise. This will allow : 1) to collect information on the physiology of the retinal vascularization to prolonged effort, 2) to detect any retinal damage (haemorrhages, edema, occlusion ...), not known to date. The results may highlight vascular effects related to retinal hypoxia (venous tortuosity, haemorrhage, venous occlusion, hypoxic edema). Furthermore the results may urge prevention in this sport more and more democratized. the investigators hypothesized that prolonged physical exercice causes a change in retinal vascularization.

Interventions

DIAGNOSTIC_TESTColor retinography

Non mydriatic color retinography within 1 month before and within 1 hour after the marathon

DIAGNOSTIC_TESTOCT-A

Optical Coherence Tomography - Angiography within 1 month before and within 1 hour after the marathon

DIAGNOSTIC_TESTBlood pressure measurement

Blood pressure measurement within 1 month before and within 1 hour after the marathon

Sponsors

Fondation Ophtalmologique Adolphe de Rothschild
Lead SponsorNETWORK

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* Person registered at the 2019 Paris Marathon

Exclusion criteria

* Ophthalmological disorders making access to the fundus impossible for both eyes

Design outcomes

Primary

MeasureTime frameDescription
Density of retinal vascular plexusesup to 1 hourPercentage, Measurement with OCT-A

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 23, 2026