Liver Cirrhosis(Who Will Undergo Planed Liver Transplantation)
Conditions
Brief summary
Prolonged corrected QT interval (QTc) has been observed in about half of patients with liver cirrhosis. Marked prolongation of QTc (ie, 500 msec) has been considered to be a risk factor for fatal ventricular arrhythmia, such as torsade de pointes,7,8 which has been reported in liver transplantation (LT) surgery. In a previous study, prolonged QTc interval ( 500 msec) was frequently observed throughout the procedure of LT, even among patients with baseline QTc 440 msec. Therefore, it is important to optimize electrolyte balance and hemodynamic status to reduce greater risk of perioperative arrhythmias. The investigators hypothesized that the change of QTc interval might be differ according to method of general anesthesia (inhalation agent vs. intravenous agent).
Interventions
DRUGinhalation (desflurane) group
Anesthesia is induced and maintained with desflurane and sufentanil
DRUGtotal intravenous (propofol) anesthesia
Anesthesia is induced and maintained with propofol and sufentanil
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Masking description
patients will be randomly allocated to 2 groups using computer-generated randomization method. Care provider will not be blinded to the group allocation, because anesthesiologists should be aware of the method of anesthesia.
Intervention model description
Arm 1: inhalation anesthesia (desflurane) group Arm 2: total intravenous anesthesia (propofol) group
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients with liver cirrhosis who will undergo planned liver transplantation
Exclusion criteria
* 1\. emergent liver transplantation * 2\. unstable angina * 3\. recent MI(Myocardial Infarction) * 4\. uncontrolled hypertension (diastolic BP \> 110mmHg) * 5\. implantable cardiac defibrillator * 6\. severe obesity (BMI\>30kg/m2) * 7\. allergy to propofol
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| QTc interval | 3 minutes after liver reperfusion | The investigator will assess the QTc interval 3 minutes after the reperfusion during liver transplantation. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| QTc interval | at the end of the surgery | The investigator will assess the QTc interval at the end of liver transplantation. |
Countries
South Korea
Outcome results
None listed