Lateral Sinus Thrombosis, Mastoiditis, Otitis Media
Conditions
Keywords
otitis media, mastoiditis, Lateral Sinus Thrombosis, subperiosteal abscess, sigmoid sinus, mastoid, mastoidectomy, ventilation tube
Brief summary
The aim of this study is to report the clinical presentation, Microbiological, laboratory and imaging evaluation, prothrombotic factors analysis, medical and surgical management and outcomes in children with Otogenic Cerebral Sinus Vein Thrombosis (CSVT).
Detailed description
Objective: Otogenic Cerebral Sinus Vein Thrombosis (CSVT) is a rare but serious intracranial complication of otitis media in children. The aim of this study is to report the clinical presentation, Microbiological, laboratory and imaging evaluation, prothrombotic factors analysis, medical and surgical management and outcomes in children with otogenic CSVT. Study design: Retrospective case series
Interventions
None listed
Sponsors
HaEmek Medical Center, Israel
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* age of 18 years or younger * both sexes are included * a clinical or radiological finding of mastoiditis in the patient's file * Documentation of CSVT in an imaging study, either CT or MRI. Patient's
Exclusion criteria
* age above 18 years * lack of a clinical or radiological finding of mastoiditis in the patient's file * Lack of documentation of CSVT in an imaging study, either CT or MRI. * previous unprovoked venous thromboembolism event.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical Presentation | All cases and follow up documentation reported up to a designated date 31 August 2018 predetermined by the institutional ethics committee | Clinical presentation signs and symptoms will be collected and a summary will be represented in a table including all subjects |
| Cultures result | All cases and follow up documentation reported up to a designated date 31 August 2018 predetermined by the institutional ethics committee | the results of cultures from blood, ear secretions, surgery samples, and PCR(polymerize chain reaction assay) will be summarized for the percentage of each pathogen and number of positive results from each type of test |
| Morbidity and Mortality | All cases and follow up documentation reported up to a designated date 31 August 2018 predetermined by the institutional ethics committee | The percentage of Morbidity and Mortality until the end of the follow-up period. Morbidity will include any long term sequelae including permanent neurological deficits, chronic ear inflammation, recurrent mastoiditis, and recurrent thromboembolic events. |
| Surgical intervention | All cases and follow up documentation reported up to a designated date 31 August 2018 predetermined by the institutional ethics committee | Summary of all surgical interventions, and determination of the common types of surgery performed. |
| Thrombophilia evaluation tests | All cases and follow up documentation reported up to a designated date 31 August 2018 predetermined by the institutional ethics committee | Thrombophilia evaluation test results will be collected and a summary will be represented in a table including all subjects |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Imaging Studies results | All cases and follow up documentation reported up to a designated date 31 August 2018 predetermined by the institutional ethics committee | Common diagnosis and distribution of CSVT as mentioned by the radiologist's reports |
Countries
Israel
Outcome results
None listed