COPD, Pulmonary Disease, Rehabilitation
Conditions
Keywords
chronic obstructive pulmonary disease, heated humidified high-flow nasal cannula, pulmonary rehabilitation, six-minute walking test
Brief summary
The aim of this study is to investigate the use heated humidified high-flow nasal cannula (HHHFNC) in pulmonary rehabilitation and analysis of cardiopulmonary parameters in adult patients.
Detailed description
Objectives： The aim of this study is to investigate the use heated humidified high-flow nasal cannula (HHHFNC) in pulmonary rehabilitation and analysis of cardiopulmonary parameters in adult patients. Background： Recently, HHHFNC has been used in both adult and neonates with post-extubation respiratory support. Studies indicate that HHHFNC has similar efficacy compared to non-invasive positive pressure ventilation and superior than conventional oxygen therapy. Six-minute walking test (6-MWT) is a standardized laboratory tests to evaluate the endurance capacity in adult patients. It helps clinician to modify the treatment plan. Cirio, et at. has been shown HHHFNC may improve the exercise performance in severe chronic obstructive pulmonary disease (COPD) patients with ventilatory limitation. Study Design： This is a prospective clinical trial in a pulmonary rehabilitation out-patient department (2018.08.01-2019.07.31).。 Methods： Patents with COPD who done pulmonary function test will enroll to this study. Left-side heart failure, COPD acute-exacerbation (AE) within 3 months, diagnosed neuromuscular disease, and unable to perform 6-MWT will be exclude. The data will be collected for and analyzed. Effect： Investigators expect the exercise performance; cardiopulmonary function will be improve under HHHFNC support. We hope the application of HHHFNC in adult patient with pulmonary rehabilitation could enhance the quality of life. Key words： chronic obstructive pulmonary disease; heated humidified high-flow nasal cannula; pulmonary rehabilitation, six-minute walking test.
Interventions
DEVICEHHHFNC
HHHFNC setting: 1. Flow rate: 40L/min 2. FiO2: 0.4 HHHFNC will use immediately before 6MWT and remove at the end of 6MWT
Sponsors
Fu Jen Catholic University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Participants with COPD who done pulmonary function test will enroll to this study. Left-side heart failure, COPD AE within 3 months, diagnosed neuromuscular disease, and unable to perform 6-MWT will be exclude. Participants will received HHHNFC or non-HHHFNC support during the 6-MWT.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* COPD with performed pulmonary function test
Exclusion criteria
* Left-side heart failure * COPD exacerbation within 3 month * Diagnosed neuromuscular disease * Unable to perform 6-MWT
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Walking distance | 6 minutes | Meter |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Heart rate | 1 hour | beat per minute |
| Oxygen saturation (SpO2) | 1 hour | — |
| Transcutaneous carbon dioxide (PtcCO2) | 1 hour | mmHg |
| Cardiac output by non-invasive cardiometry | 1 hour | mL |
| Borg dyspnea scale | 1 hour | 0-10 level (level 10 means worst) |
Countries
Taiwan
Outcome results
None listed