Soft Markers
Conditions
Keywords
Anomaly scan, Anuploidy
Brief summary
The purpose of this study is to investigate the prevalence of soft markers which will be identified during a second trimester ultrasound. Secondary aims were to estimate the association between the soft markers and trisomies 13, 18 and 21 as well as the effect on the number of invasive tests will be performed.
Interventions
DEVICEMidtrimester anomaly scan
A detailed anomaly scan to detect soft markers at 16 to 24 weeks pregnancy
GENETICFetal Karyotyping
Fetal karyotyping after birth to confirm chromosomal anomaly diagnosed clinically
Sponsors
Cairo University
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
1. pregnant woman between (16-24) weeks of gestation. 2. singelton pregnancy.
Exclusion criteria
1. Multiple pregnancies. 2. Mental condition rendering the patients unable to understand the nature and scope of the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To study the association between soft markers identified at second trimester ultrasound and aneuploidy. | 1 year | fetal soft markers detection which include the following: * choroid plexus cyst. * Mild ventriculomegaly. * Enlarged cistern magna. * Nasal bone hypoplasia. * Increased nuchal fold. * Echogenic cardiac focus. * Single umbilical artery. * Pyelectasis. * Echogenic bowl. * Short femur. * Short humerus. All data will be collected and statistics will be done for the correlation between one or more soft markers with structural anomalies and its relation with aneuploidy. |
Countries
Egypt
Outcome results
None listed