Acute Kidney Injury, Cardiac Disease
Conditions
Keywords
Acute Kidney Injury, cardiopulmonary bypass, brush-border enzymes of the proximal renal tubules, ischemia modified albumin
Brief summary
Cardiac surgery related acute kidney injury (CS-AKI) is a clinical problem associated with a cardiopulmonary bypass used during cardiac surgery procedures. In this study the investigators will assess the biochemical markers of acute kidney injury such as ischemia modified albumin (IMA) or urinary excreted of brush-border enzymes of the proximal renal tubules perioperatively. There has been no official recommendations toward routine use of analysed biomarkers.
Detailed description
Cardiac surgery related acute kidney injury (CS-AKI) is an important clinical problem. Kidney injury occurs following a cardiopulmonary bypass used during cardiac surgery procedures. The pathomechanisms of acute kidney injury (AKI) is complex and multifactorial. It may involve few injury pathways: ischemia and reperfusion, endogenous toxins, inflammation, metabolic factors and oxidative stress. Biochemical markers of acute kidney injury such as ischemia modified albumin (IMA) or urinary excreted of brush-border enzymes of the proximal renal tubules analysed perioperatively will be assessed in this study. There has been no official recommendations toward routine use of analysed biomarkers.
Interventions
DIAGNOSTIC_TESTurine and blood analysis
concentration of ischemia modified albumin assessed in blood before operation, immediately and one hour after cardiopulmonary bypass, 24 hours after operation; concentration of urinary excretion of brush-border enzymes of the proximal renal tubules assessed before operation, immediately and one hour after cardiopulmonary bypass, 24 hours after operation, serum creatinine levels will be evaluated on the day of the operation and 24 h and 48 h postoperatively
Sponsors
Pomeranian Medical University Szczecin
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* a planned operation of coronary artery bypass grafting with the use of cardiopulmonary bypass
Exclusion criteria
* emergency operations or re-operations; * a known pathology of the urinary tract or renal failure; * chronic use of the following medications: iron, non-steroidal anti-inflammatory drugs (NSAIDs), immunosuppression, or steroids in the preoperative period; * polycythemia, porphyria or pathological hemoglobin species in anamnesis; * preoperative signs of hepatic failure; * active autoimmune or neoplastic diseases, active infection; * anticipated significant bleeding (anti-platelet agents), suggesting the use of blood-derived products during the operation and afterward * acute myocardial infarction after operation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| acute kidney injure after operation | up to 48 hours post operation | acute kidney injure measured by creatinine concentration mg/dl |
Countries
Poland
Outcome results
None listed