Different Volatile Anaesthetics and the Depth of Long Term ICU Sedation

Depth of Long Term ICU Sedation Under 0,5 MAC Isoflurane, Sevoflurane or Desflurane Using MIRUS, an Automated Delivery System for Volatile Anaesthetics

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03860129

Enrollment

Registered

2019-03-01

Start date

2014-12-10

Completion date

2017-05-31

Last updated

2019-03-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intensive Care Unit Syndrome

Keywords

inhalational Sedation

Brief summary

The MIRUS system (TIM, Andernach, Germany) as well as the AnaConDa uses a reflector to conserve volatile anaesthetics (VA). Both systems can be paired with ICU ventilators, but MIRUS features an automated control of end-tidal VA concentrations (etVA). We compare depth of 0.5 MAC inhalational long-term sedation with Isoflurane (ISO), Sevoflurane (SEVO) or Desflurane (DES).

Detailed description

The study was approved by the appropriate Institutional Review Board. Thirty ASA II-IV patients, undergoing elective or emergency surgery under general anaesthesia were included and randomized into three equal groups: ISO, SEVO or DES. We used MIRUS, a gas delivery system with a VA reflector, just like AnaConDa, that can be paired with common ICU ventilators. Additionally, MIRUS features the unique ability to maintain the end-tidal concentration (etVA) in target by automatically adjusting the delivery rate. Every 8 hours, the RASS was assessed by the nurse. The log of the EEG-Narcotrend Index (NI) was also included in the study.

Interventions

DRUGIsoflurane

Group A: Isoflurane (0.5 MAC)

DRUGSevoflurane

Group B: Sevoflurane (0.5 MAC)

DRUGDesflurane

Group C: Desflurane (0.5 MAC)

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

HEALTH_SERVICES_RESEARCH

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Signing of the informed consent document (patient or relatives). * Patient age 18 years or older. * ASA I-III

Exclusion criteria

* ASA IV patients * Epidural or spinal analgesia * Allergy or known hypersensitivity to any of the study drugs * Patients with known or suspected genetic susceptibility to malignant hyperthermia * Previous participation in this trial * Participation in another clinical trial within 4 weeks prior to selection. * Pregnant women

Design outcomes

Primary

Measure	Time frame	Description
usage of volatile anesthetics at 0.5 MAC during ICU Sedation	up to one week	Comparison between Isofluarne, Sevoflurane and Desflurane

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 1, 2026