Non-invasive Ventilation, Pediatric Pulmonary Disease
Conditions
Keywords
Bronchiolitis, Emergency department, High-flow nasal cannula, Flow rate
Brief summary
Objective: The investigators aimed to compare the heated humidified high-flow nasal cannula (HHHFNC) flow rate of 1-L/kg/min (1L) with 2-L/kg/min (2L) in patients with severe bronchiolitis presenting to the pediatric emergency department. Study design: The investigators performed a study in which all patients were allocated to receive these two flow rates. The primary outcome was admitted as treatment failure, which was defined as a clinical escalation in respiratory status. Secondary outcomes covered a decrease of respiratory rate (RR), heart rate (HR), the clinical respiratory score (CRS), rise of peripheral capillary oxygen saturation (SpO2) and rates of weaning, intubation and intensive care unit (ICU) admission. Keywords: Bronchiolitis, Emergency department, High-flow nasal cannula, Flow rate
Interventions
DEVICEHeated humidified high-flow nasal cannula
Non-invasive ventilation with a nasal cannula
Sponsors
Ege University
Ali Yurtseven
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Days to 2 Years
Healthy volunteers
Yes
Inclusion criteria
* Clinical diagnosis of severe bronchiolitis * Must be less than 24 months * Must have presented to the emergency department
Exclusion criteria
* Immediate invasive ventilation and/or intensive care unit admission * Congenital heart disease, * Chronic lung disease * Neuromuscular disease * Netabolic disease * Craniofacial anomalies * Immunocompromised * Bacterial pneumonia * Pneumothorax * Nasal trauma
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Treatment failure rate | Within 24 hours | We compared the treatment failure between the 1-L/kg/min flow rate with 2-L/kg/min rate in patients with severe bronchiolitis |
Countries
Turkey (Türkiye)
Outcome results
None listed