Protocol PERCAF 2018

Conditions

Caffeine, Polymorphism, Sleep

Keywords

sleep deprivation, cognition, attention

Brief summary

In this multicentric controlled study, we aims to evaluate effect of caffeine on mental performances during a sleep deprivation protocol. Genetic polymorphisms are considered as a covariable.

Detailed description

Coffee is the most consumed arousing substance in the world. Caffeine is used as a natural countermeasure to maintain the performance of sleep deprived subjects. However, the effectiveness of caffeine is characterized by a large individual variability, also observed on side effects. This variability could notably be related to polymorphisms of the adenosine receptor 2a gene (ADORA2A) and Tumor Necrosis Factor-alpha, a pro-inflammatory cytokine whose increase is observed during sleep deprivation. This study, under conditions of total sleep deprivation in the laboratory (40 hours of continuous awakening), examine the cross-influence of two polymorphisms (ADORA2A: rs5751876 and TNF-alpha: rs1800629) on the sensitivity to caffeine and on the degradation of attentional performances. Physical performance, mental performance, immuno-inflammatory responses and the occurrence indesirable effects will be evaluate. This work aims to understand the mechanisms that contribute to increasing individual vulnerability and promoting protective countermeasures. The purpose of this project is to improve the recommendations concerning the daily use of caffeine and during periods of prolonged awakening, particularly in the military environment.

Lourdes Mateo, Pierre-Emmanuel Tardo-Dino, D. Gomez-Merino, Catherine Drogou, Pierre-Emmanuel Josse et al. (13 authors)

Frontiers in Cardiovascular Medicine2026-01-30

10.3389/fcvm.2026.1718154

Impact of acute caffeine intake on local tolerance to cold before and after total sleep deprivation

Baptiste de Lorgeril, Pierre‐Emmanuel Tardo‐Dino, Cyprien Bourrilhon, Michaël Quiquempoix, Catherine Drogou et al. (12 authors)

Experimental Physiology2025-03-27

10.1113/ep092356

Caffeine Intake Alters Recovery Sleep after Sleep Deprivation

Benoit Pauchon, Vincent Beauchamps, Danielle Gomez-Mérino, Mégane Erblang, Catherine Drogou et al. (11 authors)

Nutrients2024-10-1110 citations

10.3390/nu16203442

Effects of Acute Caffeine Intake on Insulin-Like Growth Factor-1 Responses to Total Sleep Deprivation: Interactions with COMT Polymorphism – A Randomized, Crossover Study

Catherine Drogou, Fabien Sauvet, Mégane Erblang, Damien Léger, Claire Thomas et al. (8 authors)

Lifestyle Genomics2023-01-011 citations

10.1159/000529897

Genetics and Cognitive Vulnerability to Sleep Deprivation in Healthy Subjects: Interaction of ADORA2A, TNF-α and COMT Polymorphisms

Mégane Erblang, Catherine Drogou, Danielle Gomez-Mérino, Arnaud Rabat, Mathias Guillard et al. (17 authors)

Life2021-10-197 citations

10.3390/life11101110

Genetic Determinants of Neurobehavioral Responses to Caffeine Administration during Sleep Deprivation: A Randomized, Cross Over Study (NCT03859882)

Mégane Erblang, Fabien Sauvet, Catherine Drogou, Michaël Quiquempoix, Pascal Van Beers et al. (14 authors)

Genes2021-04-1019 citations

10.3390/genes12040555

Interventions

OTHERSleep deprivation

40 hours of continuous awaking in the sleep laboratory in order to compare before and after sleep deprivation for each treatment (Caffeine vs. placebo).

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy subject

Exclusion criteria

* Treatment * History of cardiovascular, psychiatric, pneumologic, haematologic, cancerology disease * Nonvoluntary * Pregnancy

Design outcomes

Primary

Measure	Time frame	Description
Psychomotor vigilance test Speed	Change from Baseline Psychomotor vigilance test Speed at day 2 after 24 hours awaking	Speed at the Psychomotor vigilance test test

Secondary

Measure	Time frame	Description
Cognitive performance	Change from Baseline at day 2 after 25 hours awaking	Number of errors at executive performance test
Force -velocity	Change from Baseline at day 2 after 32 hours awaking	Power at the force-velocity test

Countries

France

Outcome results

None listed