Type1 Diabetes Mellitus
Conditions
Brief summary
Type 1 diabetes mellitus is a common autoimmune disease. It affects women of all ages including reproductive years. Hyperglycemic condition in diabetes can cause organ damage. This study aims to measure serum hormones including FSH, LH, E2, AMH, ovarian volume and antral follicle count (indicators of ovarian reserve) in women with and without type 1 diabetes mellitus.
Detailed description
Type 1 diabetes mellitus is a common autoimmune disease. It affects women of all ages including reproductive years. It is showed that hyperglycemic state in diabetes results in organ damage like kidneys and eyes. Ovarian reserve is important for the reproductive period. The measurements of serum hormones including follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2) and anti-mullerian hormone (AMH) will give us an idea about the ovarian reserve. The investigators aim is to measure ovarian reserve parameters in patients diagnosed with type 1 diabetes mellitus and to compare them to healthy controls. Serum FSH, LH, E2 and AMH will be measured on the 3rd day of the cycle. Antral follicle count and ovarian volume measurement will be done with ultrasonography. Ovarian reserve markers will be compared between the groups.
Interventions
OTHERhormone panel and ultrasonography
Blood sampling on the 3rd day of menstrual cycle for the measurement of serum FSH, LH, E2 and AMH hormone levels and ultrasonography for antral follicle count and ovarian volume measurement will be done.
Sponsors
Kanuni Sultan Suleyman Training and Research Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Reproductive age group women: 18-40 years * Women diagnosed with type 1 diabetes (case group) * Women without type 1 diabetes (control group)
Exclusion criteria
* Women with PCOS (polycystic ovary syndrome) * history of ovarian surgery * Body mass index (BMI) over 30
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| E2, FSH, LH, AMH levels | during procedure | E2, FSH, LH, AMH levels of blood samples will be measured |
| antral follicle count | during procedure | antral follicles of ovaries will be counted with ultrasonography |
| ovarian volume | during procedure | both ovaries will be measured in three dimensions with ultrasonography |
Countries
Turkey (Türkiye)
Outcome results
None listed