Surgical Site Infection
Conditions
Keywords
Colony forming units, preoperative skin disinfection, microbial skin counts
Brief summary
This observational study investigates whether 3 paints are superior compared to 2 paints in reducing microbial skin counts in the disinfection area of cardiac and abdominal surgery patients.
Detailed description
Surgical site infection (SSI) remain the most common nosocomial infection in surgical departments. Preparation of the skin with disinfectants belongs to the standard of care prior to any surgical intervention but disinfection practices are heterogeneous across different hospitals and countries. Although the efficacy and effectiveness of preoperative surgical site preparation is dependent on both the antiseptic agent used and the application method, it is unclear how many paints of an antiseptic are needed to ensure adequate infection protection. An adequately powered study including different standard antiseptic agents (i.e. chlorhexidine in alcohol (CHX) and povidone iodine in alcohol (PI)) is therefore required to compare the protective effect of different numbers of paints.
Interventions
OTHERmicrobial skin counts in the disinfection area after paints of skin disinfectants
microbial skin counts in the disinfection area after 2 and 3 paints of skin disinfectants (chlorhexidine in alcohol \[CHX\] and povidone iodine in alcohol \[PI\])
Sponsors
Swiss National Science Foundation
University Hospital, Basel, Switzerland
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patients undergoing elective cardiac surgery at the study site * Adult patients undergoing elective abdominal surgery at the study site * Provision of informed consent
Exclusion criteria
* Pregnancy reported by patient * Emergency (non-elective) surgical interventions * Contraindications to the use of either one of the compounds: Alcoholic CHX; Alcoholic PI * Skin or other hypersensitivity reactions during the disinfection process
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in microbial skin counts (number of Colony forming Units (CFU)) | prior to skin disinfection (T0) and after paint two (T1, approx. after 2 minutes) and after paint three (T2; approx. after 3 minutes) before start of surgery | Change in microbial skin counts (CFU) after 3 paints as compared to 2 paints |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Proportion of patients with microbial skin counts of 0 CFU after 3 paints as compared to 2 paints | after paint two (T1, approx. after 2 minutes) and after paint three (T2; approx. after 3 minutes) before start of surgery | Proportion of patients with microbial skin counts of 0 CFU after 3 paints as compared to 2 paints |
| Proportion of patients with insufficient reduction of microbial skin counts (i.e. log reduction of CFU <2) after 2 paints | after paint two (T1, approx. after 2 minutes) | Proportion of patients with insufficient reduction of microbial skin counts (i.e. log reduction of CFU \<2) after 2 paints |
Countries
Switzerland
Outcome results
None listed