Multiple Sclerosis
Conditions
Keywords
neuromuscular disease, whole-body vibration, hypoxia, strength
Brief summary
Multiple Sclerosis (ME) is a degenerative, inflammatory and autoimmune demyelinating disease of the central nervous system, characterized by demyelination due to inflammation and degeneration of the myelin sheaths enveloping nerves of the eye, periventricular grey matter, brain, spinal cord and brainstem. The symptoms associated with MS include symptomatic fatigue, muscle weakness, ataxia, mobility and balance problems or cognitive problems. Moderate intensity strength training has been shown to improve strength and mobility in persons with MS. It was suggested that whole-body vibration training (WBVT) is effective to improve muscle strength, such as resistance training, resulting from both neural and structural adaptations. On the other hand, traditional strength training in hypoxia has garnered much attention. This method has shown improvements in isometric strength and increases in muscle size.
Detailed description
* Crossover. * 13 patients with multiple sclerosis were recruited. * Patients performed two sessions: whole-body vibration training in normoxia condition and whole-body vibration in hypoxia condition.
Interventions
OTHERExercise
Whole-body vibration training in hypoxia and normoxia condition
Sponsors
Universidad Católica San Antonio de Murcia
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* mild or moderate disability with clinical mild spastic-ataxic gait disorder. * stable phase of the disease.
Exclusion criteria
* Expanded Disability Status Scale (EDSS) \< 6. * relapsing disease within the preceding 12 months. * corticosteroid treatment within the last months before study inclusion.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Spasticity | Immediately before the training sessions | Pendulum test |
| Maximal Voluntary Isometric Contraction of Knee Extension | Immediately before the training sessions | — |
| Rate of Force Development | Immediately before the training sessions | — |
| Central Activation Ratio | Immediately before the training sessions | — |
| Biomechanical study of the walk by video recording | Immediately before the training sessions | Kinematic analysis of knee and ankle angles during walking |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Walking speed | Immediately before the training sessions | Test 10 m-walks |
| Static balance | Immediately before the training sessions | Romberg Test with eyes open and closed. Analysis with force plates |
| Muscle oxygenation in soleus | Immediately before the training sessions | MOXY's |
| Rate of Perceived Exertion | Immediately before the training sessions | RPE Scale 6-20 |
Countries
Spain
Outcome results
None listed