Acute Kidney Injury
Conditions
Keywords
Acute Kidney Injury, Renal Replacement Treatment, Biomarker
Brief summary
The aim of this study was to verify the prognostic value of functional kidney biomarkers on survival and renal function recovery in cardiac surgery patients with acute kidney injury.
Detailed description
Cardiac surgery-associated acute kidney injury (CSA-AKI) is the second most common type of AKI after septic AKI and is associated with increased mortality and morbidity. Few biomarkers were validated as outcome-specific biomarkers in patients developing AKI after cardiac surgery at initiation of RRT. This study was designed to not only verify the prognostic value of functional kidney biomarkers on survival, but also predict it severity in order to optimize clinical decision making with respect to dialysis initiation and discontinuation.
Interventions
OTHERRenal Replacement Therapy
Indications for RRT were defined as previously reported. 1. Kidney Disease: Improving Global Outcomes (KDIGO) stage 2 ; 2. severe sepsis, persistence of hypotension (for more than 6 h) despite preload optimization and use of vasopressors or catecholamines (norepinephrine or epinephrine \>0.1 μg/kg/min), 3. refractory fluid overload (worsening pulmonary edema, PaO2/FiO2 \<300 mm Hg or fluid balance \>10% of body weight), 4. low probability of rapid renal recovery according to the judgment of the intensivists and nephrologists.
Sponsors
Shanghai Zhongshan Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Patients undergoing cardiac surgery who required renal replacement therapy.
Exclusion criteria
* History of End Stage Renal Disease or on Dialysis * prior kidney transplantation * patients with a DNR order or do not escalate care order
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 28-day mortality | 28 days | Death from any cause at 28 days |
| Dependence on renal-replacement therapy at 28 days in survivors | 28 days | Dependence on renal-replacement therapy was defined as surviving dependent on RRT |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Length of stay in the hospital | Up to 90 days or hospital discharge | the length of stay in the hospital |
| 60- and 90-day mortality | Up to 60 or 90 days | Death from any cause at 60- and 90-days |
| the number of days free of renal-replacement therapy, mechanical ventilation at 28 days | 28 days | the number of days free of renal-replacement therapy, mechanical ventilation at 28 days |
| Adverse events | Up to 90 days | with a focus on the complications potentially related to acute kidney injury or renal-replacement therapy during the first 7 days after enrollment |
| Length of stay in the ICU | Up to 90 days or ICU discharge | the length of stay in the ICU |
Countries
China
Contacts
Primary ContactGuo-wei Tu, PhD
Backup ContactYing Su, MD
Outcome results
None listed