Hemodynamics
Conditions
Keywords
Levosimendan, Milrinone, Off-pump, Coronary
Brief summary
To compare the efficacy of Levosimendan versus Milrinone in supporting hemodynamics during off-pump coronary artery bypass grafting surgery in patients with low ejection fraction.
Detailed description
The major challenge during off-pump coronary artery bypass graft surgery is to maintain optimum hemodynamics by optimizing the intravascular volume and by using some inotropes. However, conventional inotropes such as beta-agonists are associated with tachycardia and arrhythmia which increase myocardial oxygen demand. Levosimendan is an inodilator which exerts its positive inotropic effect by enhancing the sensitivity of troponin C to calcium without increasing intracellular calcium concentration. Levosimendan also decreases the systemic vascular resistance, so, it increases the cardiac output without increasing myocardial oxygen consumption. This study aims to compare the efficacy of Levosimendan versus Milrinone in supporting hemodynamics during off-pump coronary artery bypass grafting surgery in patients with low ejection fraction.
Interventions
DRUGLevosimendan
Intraoperative infusion of Levosimendan
DRUGMilrinone
Intraoperative infusion of Milrinone
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
30 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Elective off-pump coronary artery bypass grafting surgery. * ejection fraction \< 50%
Exclusion criteria
* Patients with severe renal impairment or renal failure. * Patients on mechanical support (intra-aortic balloon pump)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean blood pressure | Intraoperative |
| Consumption of other inotropes | Intraoperative |
Countries
Egypt
Contacts
Primary ContactHany M. Osman, M.D.
Backup ContactFatma Mohamed, M.D.
Outcome results
None listed