Mild Cognitive Impairment
Conditions
Keywords
Neurofeedback, Electroencephalography, MCI, Alzheimer
Brief summary
This is a non-pharmacological pilot study showing the improvement of a SMR/theta neurofeedback training program on cognitive performance and EEG activity in Elderly with Mild Cognitive Impairment.
Detailed description
Neurofeedback training (NF) as self-regulation method of brain activity, may be beneficial in elderly with mild cognitive impairment. In this pilot study, the investigators studied whether a sensorimotor(SMR)/theta NF training could improve cognitive performance and brain electrical activity in a sample group of elderly patients with mild cognitive impairment. Twenty participants performed an electroencephalography recording, a battery of neuropsychological tests before the neurofeedback training program (T0), following the neurofeedback training program (T1) and 1-month follow-up (T2).
Interventions
BEHAVIORALSMR neurofeedback training to MCI
The intervention consisted to increase the synaptic strengths and sensitivity within this network. Electroencephalography signals for SMR/theta training was recorded at channel Cz according to the international 10-20 system. Theta rhythm was also recorded and, in this case, SMR was stimulated while theta waves were suppressed.A 32 channels system (EEGDigitrcak Biofeedback plus module, Inc Elmiko Medical) was used for the SMR/theta Neurofeedback training.
Sponsors
Fabienne Marlats
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Intervention model description
no randomized, no controlled
Eligibility
Sex/Gender
ALL
Age
65 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Clinical diagnosis of Mild Cognitive Impairment * education level of 9 years of studies minimum * righthandedness * subjective memory complaint confirmed by an informant * a Mini Mental Status Examination score \>20. * preserve activity of daily living and absence of dementia.
Exclusion criteria
* elderly persons who were under guardianship * resident in nursing facilities * neurological disease, psychiatric disease * and involved in another cogniitve intervention.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rey Auditory Verbal Learning test | Assessment at baseline, change from baseline to 11 weeks immediately after the NF training and 1 month follow-up | Assessment of verbal learning in episodic memory, evaluating the ability to encode, combine, store and long-term consolidation process. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Relative power for delta, theta, alpha, sensorimotor and lower beta frequency bands. | Assessment at baseline, change from baseline to 11 weeks immediately after the NF training and 1 month follow-up | Electroencephalography was recorded and EEG power spectrum was calculated using the fast Fourier transform. The power spectral density was calculated to extract the relative power for each frequency band and estimated as a log-ratio. |
Outcome results
None listed