ARDS, Human, Endothelial Dysfunction, Mechanical Ventilation Pressure High
Conditions
Keywords
ARDS, Endothelial Dysfunction, mechanical ventilation, Glycocalyx, pulmonary fibrosis, mortality
Brief summary
ARDS is a severe disease in ICU, and could induce high mortality. Glycocalyx is an important matrix construction which covers endothelial cells, it could protect endothelial cells injury and the glycocalyx biomarkers could predict pulmonary injury. Decorin is a member of the small leucine-rich proteoglycan (SLRP) family, contains a single glycosaminoglycan (GAG) chain and a core protein with 12 leucine-rich repeats. In the previous study, decorin is associated with cardiac and liver fibrosis, however, the effects of decorin on ARDS pulmonary fibrosis have not been clarified.
Interventions
DIAGNOSTIC_TESTGlycocalyx measurement，respiratory mechanics measurement
ELASA measure glycocalyx, measure plateau pressure, driving pressure
Sponsors
Southeast University, China
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Inclusion criteria
1. Age \> 18yrs and \<80yrs 2. Meet ARDS Berlin definition 3. With mechanical ventilation
Exclusion criteria
1. have chronic pulmonary disease 2. have use heparin or low molecular heparin or chondroitin sulfuric acid
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 28 days mortality from patients involved in the study | 28 days | 28 days mortality from patients involved in the study |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| CT and syndecan-1 to evaluate pulmonary fibrosis | 1mon, 3mon and 6 month | pulmonary fibrosis evaluated by biomarker and CT |
| pulmonary function test to evaluate pulmonary function | 1mon, 3mon and 6 month | pulmonary function evaluated by pulmonary function test |
Countries
China
Contacts
Primary ContactChun C Pan, Dr
Outcome results
None listed