No Condition Salivary Alpha Amylase
Conditions
Brief summary
The proposed project tests the hypothesis that salivary alpha amylase concentration is a reliable biomarker of the effect of transdermal vagus nerve stimulation (tVNS) in humans.
Detailed description
The study examines the capacity of tVNS to alter the concentrations of salivary alpha amylase. Changes in salivary alpha amylase concentrations reflect alteration of CNS structures anatomically linked to the vagus, thus alertation of alpha amylase would indicate the efficacy of tVNS. This study is intended to study basic mechanisms and is not directed toward the treatment of any disease state. Particapants taking part in the study will spend about one hour in a single session.
Interventions
OTHERTransdermal Vagus Nerve Stimulation
intermittent transdermal stimulation of the aurical vagus
Sponsors
Arkansas Tech University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Healthy individuals
Exclusion criteria
* NA
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Salivary Alpha Amylase concentration. | Within single one hour session change in concentration immediately prior to and following stimulation and 5 minutes post-stimulation | Biomarker of autonomic arousal level |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Heart Rate Variability. | Within single one hour session change in heart rate variability immediately prior to and following stimulation period. | Change in beat to beat interval. |
Countries
United States
Outcome results
None listed