Using Isosorbide Mononitrate in Reducing Time in Induction of Labor in Post Date Women

Efficacy of Intravaginal Administration of Isosorbide Mononitrate Together With Misoprostol Versus Misoprostol Alone in Induction of Labor in Postdate Women

Status

UNKNOWN

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03854383

Enrollment

100

Registered

2019-02-26

Start date

2019-03-03

Completion date

2019-07-01

Last updated

2019-03-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Induction of Labor

Brief summary

We will compare between using isosorbide mononitrate together with misoprostol versus the misoprostol alone in induction of labor in postdate women

Interventions

DRUGIsosorbide mononitrate

Administration of isosorbide mononitrate vaginaly together with misoprostol in induction of labor in postdate women

DRUGMisoprostol

Used intravaginally to ripe the cevix in induction of labor

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* age (20-35 yrs) * single fetus * gestational age \> 40weeks * not in labor * bishop score \< 7 * no medical disorder

Exclusion criteria

* Gestational age ≤40 weeks * patient with a ripe cervix * rupture of membranes * suspected chorioamnionitis * placenta previa * history of major uterine surgery * hypertonic uterine pattern * contraindicated to receive PG * fetal malpresentation * multiple pregnancy * intrauterine growth retardation * women with any general medical disorder

Design outcomes

Primary

Measure	Time frame	Description
The duration of induction to active phase interval	12 weeks	Measure the time between the beginning of the induction to enter the active phase of labor

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026