Acute Pancreatitis, Chronic Pancreatitis, Fibrosis, Inflammation, Pancreatitis, Recurrent Pancreatitis
Conditions
Brief summary
Observational prospective study evaluating the developement of chronic pancreatitis based on imaging modalities as well as biochemical markers of inflammation, fibrosis and oxidative stress.
Detailed description
Chronic pancreatitis (CP) represents the end-stage of a continuous disease process evolving from acute pancreatitis (AP), over recurrent acute pancreatitis (RAP). Due to the irreversible nature of CP, early detection and prevention is key. The study uses state-of-the-art imaging modalities as well as biochemical markers of to evaluate fibrosis progression in patients with pancreatitis. The included participants have either first time AP, RAP, early CP with preserved pancreatic exocrine and endocrine function or end-stage CP with exocrine insufficiency. Included patients will be followed prospectively for 15 years with advanced MRI and contrast enhanced EUS with elastography, assessment of endocrine and exocrine pancreatic function, biochemical and nutritional assessment, and evaluation of pain processing using quantitative sensory testing. Blood for a biobank will be obtained. The purpose of the biobank is to allow analyses of potential biomarkers for the progression of disease eventually leading to CP.
Interventions
DIAGNOSTIC_TESTDiagnostic imaging
MRI assessments including magnetic resonance cholangiopancreatography (MRCP) and diffusion weighted imaging (DWI) combined with gold standard EUS
Sponsors
Copenhagen University Hospital, Hvidovre
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Inclusion criteria
* Patients with CP (N=50) of any aetiology except gallstone induced CP: CP will be diagnosed based on MANNHEIM criteria . * Cohort 2: Patients with their first attack of AP of any aetiology except gallstone induced AP (N=50). The revised Atlanta criteria for acute pancreatitis will be used as diagnostic criteria. * Cohort 3: Patients with RAP (N=50) except gallstone induced RAP. RAP is defined as two or more cases of AP as diagnosed by the revised Atlanta Criteria.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fibrosis progression on endoscopic ultrasound (EUS) or magnetic resonance imaging (MRI) | 15 years | Progression of fibrosis in the pancreas based on either EUS or MRI |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Lean body mass assessed using bioimpedance | 15 years | Body composition focusing on lean body mass will be assessed using bioimpedance |
Countries
Denmark
Contacts
Primary ContactSrdan Novovic, PhD
Backup ContactLise L Gluud, MSc
Outcome results
None listed