COPD
Conditions
Keywords
COPD, Inflammation, exercise training
Brief summary
Chronic obstructive pulmonary disease (COPD) is widely spread all over the world. It is predicted to be the third leading cause of death by 2020\[1\]. COPD is a common, preventable treatable disease that is characterized by an airflow limitation which is not fully reversable\[2\].
Detailed description
Chronic obstructive pulmonary disease (COPD) is widely spread all over the world. It is predicted to be the third leading cause of death by 2020. COPD is a common, preventable treatable disease that is characterized by an airflow limitation which is not fully reversable.Not only the long-term exposition to noxious particles and gases contributes to the development of COPD, but also so many others factors such as genetics and cigarette smoking. It has been shown that cigarettes are harmful and contributed to different extra pulmonary disorders. Indeed, it induced a systemic inflammation that was considered as a key process in the pathogenesis of COPD and triggered the activation of inflammatory cells and an abnormal increase of circulating cytokines such as CRP, interleukin (IL6), IL8, tumor necrosis factor alpha (TNF alpha) and leptin.
Interventions
OTHEREndurance Training ET
Endurance training were prformed. Intensity was gradually increased.
OTHERResistance Training RT
Resistance training were prformed. Intensity was gradually increased.
Sponsors
Faculty of Medicine, Sousse
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Caregiver, Investigator)
Eligibility
Sex/Gender
MALE
Age
40 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* COPD diagnosed by pulmonary function testing * Clinically stable * Abscence of other obstructive diseases * Signed written consent
Exclusion criteria
* Neuromuscular diseases -Severe psychiatric, neurologic or musculoskeletal conditions and /or instable--- -- * cardiovascular diseases. * Contre-indications to physical therapy * Acute exacerbations a month before the intervention
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Enzyme linked immunosorbent assay for serum cytokines levels change | Baseline, 6 months | The interleukines were determined by ELISA assays with commercial kits |
Countries
Tunisia
Outcome results
None listed