Behçet
Conditions
Keywords
Behçet disease, endocan
Brief summary
The aim of our study was to assess serum endocan levels in patients with Behcet disease and to correlate it with various disease clinical and laboratory parameters of disease activity as well as carotid intima media thickness.
Detailed description
This study will be carried out on two groups: • Group (I): Forty two patients diagnosed to have Behcets disease fulfilling the International Criteria for BD . Group (II): including 42 age and sex matching healthy volunteers as control group. (A) Clinical evaluation 1. Complete history taking. 2. Thorough clinical examination including opthalmologic evaluation . 3. Disease activity using The Behcet's disease current activity form (BD-DAF) . (B) Laboratory assessment: All patients will be subjected to the following measurements: 1. ESR 2. CRP 3. CBC 4. liver and kidney function tests d) Serum Endocan level e)triglycrides f) cholestrol C) carotid intima media thickness
Interventions
DIAGNOSTIC_TESTmeasurement of serum endocan
measurement of serum levels of endocan
Sponsors
Benha University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
16 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* patients with Behcets disease fulfilling the International Criteria for BD .
Exclusion criteria
* infection * malignancy * other connective tissue disease * chronic liver disease * chronic kidney disease * Diabetes mellitus * hypertension * hyperlipidemia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the Behcet's disease current activity form (BDCAF) | : through study completion, an average of 6 months | One point is given to the presence of different organ involvement over the 4 weeks prior to assessment as follows: headache, mouth ulcers, genital ulcers, skin lesions , joint involvement , gastrointestinal symptoms , eye involvement , nervous system involvement , and major vessel involvement.The total score will be out of 12 and higher score indicates worse outcome. we will assess the relation between serum endocan level and BDCAF |
| Erythrocyte sedimentation rate (ESR) | : through study completion, an average of 6 months | ESR measured in mm/1st hour by westergren method. we will assess the relation between serum endocan level and ESR |
| C reactive protein (CRP) | : through study completion, an average of 6 months | CRP measured in mg/L using nephlometry. we will assess the relation between serum endocan level and CRP |
| carotid intima media thickness | : through study completion, an average of 6 months | Color Doppler ultrasonography was performed for both common carotid arteries in a longitudinal orientation and measured with millimeter |
Countries
Egypt
Outcome results
None listed