Morbid Obesity
Conditions
Keywords
Bariatric surgery, gut peptides, weight loss, glycemia
Brief summary
Morbidly obese patients undergoing either Roux en Y gastric bypass or sleeve gastrectomy were examined preoperatively, 3, 6, and 12 months after surgery. On each occasion, anthropometric data were collected, resting metabolic rate was measured, and the patients underwent a panel of cardiovascular examinations (heart rate variability, baroreflex sensitivity, heart ultrasound). Following that, they consumed a test meal and completed visual analog scales for the subjective assessment of hunger and fullness every 30 minutes for 3 hours. At the same time points, blood samples were collected for the consequent measurement of glucose, insulin, lipids, and gastrointestinal hormones.
Interventions
PROCEDUREBariatric surgery
Bariatric surgery
Sponsors
Beth Israel Deaconess Medical Center
National and Kapodistrian University of Athens
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* BMI \>40 kg/m2 * Age between 18 and 65 years * Proven failure to lose weight through non-surgical interventions
Exclusion criteria
* Serious and life threatening comorbidities (renal, cardiac, liver failure, or malignancy) * Patients' inability to adhere to postsurgical instructions * Alcohol or other substance abuse * Concurrent psychiatric illness
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in postprandial ghrelin responses | 3, 6, and 12 months | Change in the cumulative postprandial response for ghrelin |
| Change in postprandial PYY responses | 3, 6, and 12 months | Change in the cumulative postprandial response for PYY |
| Change in postprandial GLP-1 responses | 3, 6, and 12 months | Change in the cumulative postprandial response for GLP-1 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in postprandial glycemia | 3, 6, and 12 months | Change in the cumulative postprandial response for glucose |
| Change in weight | 3, 6, and 12 months | Change in weight (percentage of weight lost through each procedure) |
| Change in postprandial insulinemia | 3, 6, and 12 months | Change in the cumulative postprandial response for insulin |
| Change in postprandial triglyceridemia | 3, 6, and 12 months | Change in the cumulative postprandial response for triglycerides |
Other
| Measure | Time frame | Description |
|---|---|---|
| Change in heart rate variability | 3, 6, and 12 months | Changes in heart rate variability |
| Change in Tei index | 3, 6, and 12 months | Changes in echocardiographic Tei index |
| Change in baroreflex sensitivity | 3, 6, and 12 months | Changes in baroreflex sensitivity |
| Change in aortic distensibility | 3, 6, and 12 months | Changes in aortic distensibility |
Outcome results
None listed