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Combination of Platelet-Rich Fibrin and Calcium Sulfate in Socket Augmentation

Combination of Platelet-Rich Fibrin and Calcium Sulfate in Socket Augmentation

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03851289
Enrollment
10
Registered
2019-02-22
Start date
2016-04-22
Completion date
2018-02-06
Last updated
2020-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tooth Extraction

Keywords

socket augmentation, platelet-rich fibrin, calcium sulfate, xenograft

Brief summary

This study evaluated the effectiveness of socket grafting material, combination of plate-rich fibrin and calcium sulfate. 5 subjects were grafted with this material, 5 subjects were grafted with combination of plate-rich fibrin and xenograft.

Detailed description

Calcium sulfate (CS), an alloplastic material, is widely accepted as a socket grafting material and undergoes rapid and complete resorption. Studies have shown that CS creates an osteoconductive lattice that stimulates bone ingrowth into a defect. PRF poses multiple growth factors, anti-inflammatory cytokines and adhesion molecules. It is biologically active up to one week. The combination of these 2 materials will serve as good grafting material for tooth socket, in order to preserve vertical and horizontal dimensions.

Interventions

COMBINATION_PRODUCTplatelet-rich fibrin and calcium sulfate
COMBINATION_PRODUCTplatelet-rich fibrin and xenograft

Sponsors

University of Malaya
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
ALL
Age
25 Years to 55 Years
Healthy volunteers
Yes

Inclusion criteria

* maxillary premolar teeth requiring extraction * neighboring mesial and distal sound/restored teeth present * alveolar bone level (measured from periapical radiographs) more than 50% of the root length * age ranges from 25-55 years

Exclusion criteria

* bony fenestration of the socket wall confirmed from CBCT scan * acute signs of infection * periodontally compromised teeth * absence of buccal plates * any systemic disease which may hinder the healing process

Design outcomes

Primary

MeasureTime frameDescription
volume at baselinebefore extractionmeasurements were done on radiograph (CBCT) images
vertical dimension at baselinebefore extractionmeasurements were done on radiograph (CBCT) images
horizontal dimension at baselinebefore extractionmeasurements were done on radiograph (CBCT) images
soft tissue level at baselinebefore extractionmeasurements were done on stone models

Secondary

MeasureTime frameDescription
vertical dimension after extractionfive months after extractionmeasurements were done on radiograph (CBCT) images
horizontal dimension after extractionfive months after extractionmeasurements were done on radiograph (CBCT) images
soft tissue level after extractionfive months after extractionmeasurements were done on stone models
volume after extractionfive months after extractionmeasurements were done on radiograph (CBCT) images

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 26, 2026