Effect of Two Doses of Coenzyme Q10 on Seminal Fluid and Semen Antioxidant Status

The Effect of Two Doses of Coenzyme Q10 on Seminal Fluid Parameters and Antioxidant Status: A Randomised Controlled Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03850561

Enrollment

Registered

2019-02-22

Start date

2018-06-01

Completion date

2019-01-25

Last updated

2019-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Male Infertility

Keywords

Male infertility, Coenzyme Q10, Antioxidants

Brief summary

The study was conducted to assess the impact of two doses of coenzyme Q10 on seminal fluid parameters and antioxidant status in infertile men.

Detailed description

The aim of this study was to assess the impact of two doses of coenzyme Q10 on seminal fluid parameters and antioxidant status in infertile men with idiopathic oligoasthenoteratospermia.

Interventions

DIETARY_SUPPLEMENTCoenzyme Q10 200

Coenzyme Q10 200 mg/day

DIETARY_SUPPLEMENTCoenzyme Q10 400

Coenzyme Q10 400 mg/day

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Masking description

Open Label

Intervention model description

Parallel Assignment

Eligibility

Sex/Gender

MALE

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* History of infertility of at least 12 months despite regular unprotected intercourse. Oligoasthenoteratospermia was diagnosed by semen analysis showing abnormal sperm concentration (\<15 million/ml), progressive motility (\<32%), total motility (\<40%) and morphology (\<30% WHO criteria) as defined by WHO manual for semen analysis 2010

Exclusion criteria

* Azoospermia, * Varicocele, * Genital tract infection, * Cryptorchidism, * Testicular trauma or scrotal surgery, * Endocrine disorder, * Systemic illness, * Smoking * The presence of female factor

Design outcomes

Primary

Measure	Time frame	Description
Semen volume (WHO 2010 guidelines)	3 months	Semen volume in ml
Sperm concentration in semen (WHO 2010 guidelines)	3 months	Sperm concentration in million/ml
Sperm motility in semen (WHO 2010 guidelines)	3 months	Sperm motility (%)
Sperm morphology in semen (WHO 2010 guidelines)	3 months	Normal sperm morphology (%)
Seminal plasma TAC	3 months	Seminal plasma total antioxidant capacity in mmol/ml
Seminal plasma CAT	3 months	Seminal plasma catalase in U/ml
Seminal plasma SOD	3 months	Superoxide dismutase in U/ml

Countries

Iraq

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026