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The Effects of e+Shots Energy Beverage on Mental Energy

The Effects of E+Shots Energy Beverage on Mood, Cognitive Function, Heart Rate, Blood Pressure, and Fine Motor Task Performance

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03850275
Enrollment
30
Registered
2019-02-21
Start date
2015-09-26
Completion date
2016-12-15
Last updated
2021-08-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Caffeine

Brief summary

The aim of the research project is to determine the changes in motivation to perform mental and physical tasks, feelings of vigor and fatigue, mental task vigilance and fine motor function after consumption of a commercially available energy product. The purpose of this study is determine whether e+shot, a product containing natural caffeine, will impact mood and performance up to 108 minutes post consumption compared to a sweetened solution containing synthetic caffeine.

Detailed description

Enrolled participants who are low consumers of caffeine will be administered either a placebo (3mg caffeine), caffeinated placebo (\ 100mg of caffeine) or e+shot first and then will be crossed over to receive the other two interventions. The study consists of 3 treatment periods of 108 minutes each with a washout period of 48 hours.

Interventions

DIETARY_SUPPLEMENTIntervention/treatment

Subjects received all 3 interventions Placebo \ 3mg caffeine Caffeinated placebo \ 100mg caffeine E+shots- The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.

Sponsors

Isagenix International LLC
CollaboratorINDUSTRY
Clarkson University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)

Masking description

Double-blinded placebo controlled

Intervention model description

Crosover Assignment

Eligibility

Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes

Inclusion criteria

* Ages 18-45 * Body Mass Index (BMI) \< 30 * Profile of Mood Status Short Scale (POMS) score \<13 on the energy scale * Energy and Fatigue trait scale score \<=10 * Consumption of \<200mg of caffeine/day * Consumption of \<150 servings of polyphenols/month

Exclusion criteria

* Subjects taking prescription or over the counter medications (except for oral contraceptives) for a chronic medical condition or recreational drugs will be excluded Chronic medical conditions are any health condition that is expected to last more than 3 months and requires on going medical care such as coronary artery disease, multiple sclerosis, etc.. * Women who are pregnant or may be trying to become pregnant * Women who are breastfeeding * People who have been diagnosed with heart conditions and/or hypertension * People who have liver disorders * People who have sensitivity or allergy to caffeine * People who have bipolar disorder * People who have iron deficiency * People who are allergic to plants of the Asteraceae/Compositae/Daisy family * Day of testing * Subjects who have had a change of ±2 hours of sleep from their regular sleep time will be re-scheduled. * If subjects begin taking a prescription or over the counter medication for an acute condition (i.e. required to take the prescription or over the counter medication for \< 3 months) during the study they will be given the option of continuing the study after they are no longer taking the prescription or over the counter medication or dropping out of the study. * If subjects are diagnosed with a chronic condition that requires the use of prescription medications for \> 3 months after they have started the study they will be eliminated from the study. * Resting systolic BP \> 180mmHg and diastolic BP \> 90mmHg after consuming the caffeine beverage.

Design outcomes

Primary

MeasureTime frameDescription
Change in POMS Vigorpre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutesPOMS Vigor, Scores range from 0-20 with higher scores indicating improved outcome
Change in POMS Fatiguepre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutesPOMS Fatigue Scores range from 0-20with higher scores indicating worse outcome
Change in POMS Depressionpre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutesPOMS Depression Scores range from 0-20 with higher scores indicating worse outcome
Change in POMS Anxietypre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutesPOMS Anxiety Scores range from 0-20 with higher scores indicating worse outcome
Change in POMS Angerpre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutesPOMS Anger Scores range from 0-20 with higher scores indicating worse outcome
Change in POMS Confusionpre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutePOMS Anger Scores range from -4 to 16 with higher scores indicating worse outcome
Change in Serial Subtraction 3 Task Performancepre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutesSerial subtraction 3- Number of attempts
Change in Serial Subtraction 7 Task Performancepre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutesSerial subtraction 7- Number of attempts
Change in Blood Pressurepre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutesBlood pressure- systolic and diastolic measured in mmHg
Change in Heart Ratepre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutesHeart rate- beats per minute
Change in Fine Motor Task Performancepre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes9-hole peg test- measured in seconds- The validated nine-hole peg test of finger dexterity was used to measure fine motor control. The 12 cm × 12 cm wooden pegboard contained nine holes and was placed on the desktop in front of the seated participant. There were nine 0.64 cm wide cylindrical pegs, were placed on the desktop outside of the container on the right side of the board and on the left side of the board for when the participant's right hand and left hand were tested, respectively. Participants were instructed to place one peg at a time into the pegboard holes until they were filled, and then remove each peg one at a time onto the desktop as fast as they could, first with their dominant hand and next with their non-dominant hand. Each test was performed twice.
Change in State Mental Energypre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutesState Mental Energy- scores range from 0 to 300 with higher scores indicating better outcome
Change in State Physical Energypre-beverage-0 minutes, Post beverage 1-30 minutes, Post beverage 2-68 minutes, Post beverage 3 -108 minutesState Physical Energy- scores range from 0 to 300 with higher scores indicating better outcome
Change in State Mental Fatiguepre beverage-0 minutes, post beverage 1- 30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutesState mental fatigue- scores range from 0 to 300 with higher scores indicating worse outcome
Change in State Physical Fatiguepre beverage-0, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3-108 minutesState physical fatigue- scores range from 0 to 300 with higher scores indicating worse outcome
Change in Continuous Performance Task Performance Percent Correctpre beverage-0 minutes, post beverage 1- 30 minutes, post beverage 2- 68, post beverage 3-108 minutesContinuous Performance Task- Percentage of correct responses Participants monitored a continuous series of letters (A-Z; Tahoma Regular font, size 20 pt) presented on the screen for 1000 ms. Participants were told to respond to the detection of the letter X only when it was preceded by the letter A by striking the left key on the key pad. The task was scored for percentage of target strings correctly detected, errors of omission (missed targets), average reaction time for correct detections, and the number of false alarms. The task lasted for two minutes and 48 targets were randomly presented
Change in Continuous Performance Task Performance Number Incorrectpre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3-108 minutesContinuous Performance Task- Number of incorrect responses
Change in Continuous Performance Task Performance Missed Responsespre beverage-0 minutes, post beverage 1- 30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutesContinuous Performance Task- Percentage of missed responses
Change in Continuous Performance Task Performance Reaction Time Correct Responsespre beverage-0 minutes, post beverage 1- 30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutesContinuous Performance Task- reaction time for correct responses
Change in Rapid Visual Input Processing Task Performance Primary Task Percentage Correctpre beverage- 0 minutes, post beverage 1- 30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutesRapid Visual Input Processing task- Primary task- percentage correct
Change in Rapid Visual Input Processing Task Performance Primary Task Percent Missedpre beverage-0 minutes, post beverage 1- 30 minutes, post beverage 2-68 minutes, post beverage 3- 108 minutesRapid Visual Input Processing task- Primary task- percentage missed
Change in Rapid Visual Input Processing Task Performance Primary Task Incorrect Responsespre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutesRapid Visual Input Processing task- Primary task- incorrect responses
Change in Rapid Visual Input Processing Task Performance Primary Task Reaction Time for Percent Correctpre beverage- 0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutesRapid Visual Input Processing task- Primary task- reaction time for percent correct
Change in Rapid Visual Input Processing Task Performance Secondary Task Percent Correctpre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutesRapid Visual Input Processing task- Secondary task- percentage correct
Change in Rapid Visual Input Processing Task Performance Secondary Task Percentage Missed Responsespre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutesRapid Visual Input Processing task- Secondary task- percentage missed responses
Change in Rapid Visual Input Processing Task Performance Secondary Task Incorrect Responsespre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3-108 minutesRapid Visual Input Processing task- Secondary task- incorrect responses
Change in Rapid Visual Input Processing Task Performance Secondary Task Reaction Time for Correct Responsespre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutesRapid Visual Input Processing task- Secondary task- reaction time for correct responses
Change in Rapid Visual Input Processing Task Performance Tertiary Task Percentage Correct Responsespre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutesRapid Visual Input Processing task- Tertiary task- percentage correct responses
Change in Rapid Visual Input Processing Task Performance- Tertiary Task Percent Missed Responsespre beverage-0 minute, post beverage-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutesRapid Visual Input Processing task- Tertiary task- percentage missed responses
Change in Rapid Visual Input Processing Task Performance Tertiary Task Number of Incorrect Responsespre beverage-0 minutes, post beverage 1- 30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutesRapid Visual Input Processing task- Tertiary task- number of incorrect responses
Change in Rapid Visual Input Processing Task Performance Tertiary Task Reaction Time for Correct Responsespre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutesRapid Visual Input Processing task- Tertiary task- reaction time for correct responses

Participant flow

Recruitment details

After screening 1035 surveys, 30 participants completed the study (see Figure 1). Recruitment and data collection lasted from September 25th 2015 to December 10th, 2016 until 30 participants had completed all 3 days of treatment. There were no harms or unintended consequences for any of the interventions.

Pre-assignment details

43 participants were randomized. Of the 43 participants who were randomized, 13 did not start the study due to scheduling conflicts and were un-enrolled from the study.

Participants by arm

ArmCount
Placebo, Then Caffeinated Placebo, Then e+Shots
Participants received the placebo and were tested for 108 minutes after consumption. After a 48 hour washout period, they received the caffeinated placebo and tested for 108 minutes. After another 48 hour washout period they received the e+shot and were tested for 108 minutes
5
Placebo, Then e+Shots, the Caffeinated Placebo
Participants received the placebo and were tested for 108 minutes after consumption. After a 48 hour washout period, they received the e+shots and tested for 108 minutes. After another 48 hour washout period they received the caffeinated placebo and were tested for 108 minutes
5
Caffeinated Placebo, Then Placebo, Then e+Shots
Participants received the caffeinated placebo and were tested for 108 minutes after consumption. After a 48 hour washout period, they received the placebo and tested for 108 minutes. After another 48 hour washout period they received the e+shot and were tested for 108 minutes
5
Caffeinated Placebo, Then e+Shots, Then Placebo
Participants received the caffeinated placebo and were tested for 108 minutes after consumption. After a 48 hour washout period, they received the e+shot and tested for 108 minutes. After another 48 hour washout period they received the placebo and were tested for 108 minutes
5
E+Shots, Then Placebo, Then Caffeinated Placebo
Participants received the e+shot and were tested for 108 minutes after consumption. After a 48 hour washout period, they received the placebo and tested for 108 minutes. After another 48 hour washout period they received the caffeinated placebo and were tested for 108 minutes
5
E+Shot, Then Caffeinated Placebo, Then Placebo
Participants received the e+shot and were tested for 108 minutes after consumption. After a 48 hour washout period, they received the caffeinated placebo and tested for 108 minutes. After another 48 hour washout period they received the placebo and were tested for 108 minutes
5
Total30

Baseline characteristics

CharacteristicPlacebo, Then Caffeinated Placebo, Then e+ShotsPlacebo, Then e+Shots, the Caffeinated PlaceboCaffeinated Placebo, Then Placebo, Then e+ShotsCaffeinated Placebo, Then e+Shots, Then PlaceboE+Shots, Then Placebo, Then Caffeinated PlaceboE+Shot, Then Caffeinated Placebo, Then PlaceboTotal
Age, Continuous19.4 years
STANDARD_DEVIATION 1.34
21.8 years
STANDARD_DEVIATION 5.85
22 years
STANDARD_DEVIATION 3.94
20 years
STANDARD_DEVIATION 1.87
20.4 years
STANDARD_DEVIATION 2.88
26 years
STANDARD_DEVIATION 6.89
21.8 years
STANDARD_DEVIATION 4.4
Height165.61 cm
STANDARD_DEVIATION 15.28
164.59 cm
STANDARD_DEVIATION 10.38
163.58 cm
STANDARD_DEVIATION 8.91
164.59 cm
STANDARD_DEVIATION 16.4
179.32 cm
STANDARD_DEVIATION 6.86
174.75 cm
STANDARD_DEVIATION 17.08
169.6 cm
STANDARD_DEVIATION 12.4
Race (NIH/OMB)
American Indian or Alaska Native
0 Participants0 Participants0 Participants0 Participants0 Participants0 Participants0 Participants
Race (NIH/OMB)
Asian
1 Participants2 Participants0 Participants0 Participants0 Participants1 Participants4 Participants
Race (NIH/OMB)
Black or African American
1 Participants1 Participants0 Participants0 Participants0 Participants2 Participants4 Participants
Race (NIH/OMB)
More than one race
1 Participants0 Participants0 Participants0 Participants0 Participants0 Participants1 Participants
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
0 Participants0 Participants0 Participants0 Participants0 Participants0 Participants0 Participants
Race (NIH/OMB)
Unknown or Not Reported
0 Participants0 Participants0 Participants0 Participants0 Participants0 Participants0 Participants
Race (NIH/OMB)
White
2 Participants2 Participants5 Participants5 Participants5 Participants2 Participants21 Participants
Sex: Female, Male
Female
2 Participants3 Participants4 Participants3 Participants2 Participants3 Participants17 Participants
Sex: Female, Male
Male
3 Participants2 Participants1 Participants2 Participants3 Participants2 Participants13 Participants
Weight67.68 kg
STANDARD_DEVIATION 9.47
67.27 kg
STANDARD_DEVIATION 25.62
66.73 kg
STANDARD_DEVIATION 12.48
67.18 kg
STANDARD_DEVIATION 17.64
71.18 kg
STANDARD_DEVIATION 7.58
74.91 kg
STANDARD_DEVIATION 16.3
67.6 kg
STANDARD_DEVIATION 11

Adverse events

Event typeEG000
affected / at risk
EG001
affected / at risk
EG002
affected / at risk
deaths
Total, all-cause mortality
— / —— / —— / —
other
Total, other adverse events
0 / 300 / 300 / 30
serious
Total, serious adverse events
0 / 300 / 300 / 30

Outcome results

Primary

Change in Blood Pressure

Blood pressure- systolic and diastolic measured in mmHg

Time frame: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in Blood PressurePre-beverage-0 minutes111.80 mmHgStandard Deviation 12.22
PlaceboChange in Blood PressurePost-beverage 3-108 minutes112.30 mmHgStandard Deviation 13.37
PlaceboChange in Blood PressurePost-beverage 1- 30 minutes109.53 mmHgStandard Deviation 12.62
PlaceboChange in Blood PressurePost-beverage 2-68 minutes111.30 mmHgStandard Deviation 15.5
Caffeinated PlaceboChange in Blood PressurePost-beverage 2-68 minutes73.60 mmHgStandard Deviation 12.14
Caffeinated PlaceboChange in Blood PressurePre-beverage-0 minutes71.00 mmHgStandard Deviation 8.51
Caffeinated PlaceboChange in Blood PressurePost-beverage 3-108 minutes72.57 mmHgStandard Deviation 8.02
Caffeinated PlaceboChange in Blood PressurePost-beverage 1- 30 minutes71.30 mmHgStandard Deviation 8.12
E+ShotsChange in Blood PressurePost-beverage 1- 30 minutes113.60 mmHgStandard Deviation 13.74
E+ShotsChange in Blood PressurePre-beverage-0 minutes111.00 mmHgStandard Deviation 16.18
E+ShotsChange in Blood PressurePost-beverage 2-68 minutes114.57 mmHgStandard Deviation 16.45
E+ShotsChange in Blood PressurePost-beverage 3-108 minutes114.67 mmHgStandard Deviation 14.21
E+Shot DiastolicChange in Blood PressurePre-beverage-0 minutes71.50 mmHgStandard Deviation 9.44
E+Shot DiastolicChange in Blood PressurePost-beverage 3-108 minutes72.03 mmHgStandard Deviation 10.32
E+Shot DiastolicChange in Blood PressurePost-beverage 2-68 minutes74.80 mmHgStandard Deviation 17.78
E+Shot DiastolicChange in Blood PressurePost-beverage 1- 30 minutes72.30 mmHgStandard Deviation 7.91
Caffeinated Placebo SystolicChange in Blood PressurePost-beverage 1- 30 minutes114.93 mmHgStandard Deviation 16.41
Caffeinated Placebo SystolicChange in Blood PressurePre-beverage-0 minutes109.63 mmHgStandard Deviation 12.99
Caffeinated Placebo SystolicChange in Blood PressurePost-beverage 2-68 minutes113.40 mmHgStandard Deviation 15.07
Caffeinated Placebo SystolicChange in Blood PressurePost-beverage 3-108 minutes112.80 mmHgStandard Deviation 15.04
Caffeinated Placebo DiastolicChange in Blood PressurePost-beverage 1- 30 minutes74.07 mmHgStandard Deviation 7.7
Caffeinated Placebo DiastolicChange in Blood PressurePre-beverage-0 minutes68.97 mmHgStandard Deviation 9.04
Caffeinated Placebo DiastolicChange in Blood PressurePost-beverage 3-108 minutes73.17 mmHgStandard Deviation 8.45
Caffeinated Placebo DiastolicChange in Blood PressurePost-beverage 2-68 minutes74.37 mmHgStandard Deviation 8.2
Primary

Change in Continuous Performance Task Performance Missed Responses

Continuous Performance Task- Percentage of missed responses

Time frame: pre beverage-0 minutes, post beverage 1- 30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in Continuous Performance Task Performance Missed ResponsesPre beverage-0 minutes16.08 PercentageStandard Deviation 25.53
PlaceboChange in Continuous Performance Task Performance Missed ResponsesPost 1 beverage-30 minutes22.21 PercentageStandard Deviation 24.49
PlaceboChange in Continuous Performance Task Performance Missed ResponsesPost 2 beverage- 60 minutes20.21 PercentageStandard Deviation 23.72
PlaceboChange in Continuous Performance Task Performance Missed ResponsesPost 3 beverage- 108 minutes20.91 PercentageStandard Deviation 24.73
Caffeinated PlaceboChange in Continuous Performance Task Performance Missed ResponsesPost 3 beverage- 108 minutes13.60 PercentageStandard Deviation 16.47
Caffeinated PlaceboChange in Continuous Performance Task Performance Missed ResponsesPre beverage-0 minutes19.54 PercentageStandard Deviation 29.5
Caffeinated PlaceboChange in Continuous Performance Task Performance Missed ResponsesPost 2 beverage- 60 minutes17.05 PercentageStandard Deviation 27.88
Caffeinated PlaceboChange in Continuous Performance Task Performance Missed ResponsesPost 1 beverage-30 minutes21.81 PercentageStandard Deviation 27.49
E+ShotsChange in Continuous Performance Task Performance Missed ResponsesPost 3 beverage- 108 minutes14.44 PercentageStandard Deviation 14.23
E+ShotsChange in Continuous Performance Task Performance Missed ResponsesPost 1 beverage-30 minutes16.68 PercentageStandard Deviation 21.01
E+ShotsChange in Continuous Performance Task Performance Missed ResponsesPost 2 beverage- 60 minutes14.73 PercentageStandard Deviation 22.34
E+ShotsChange in Continuous Performance Task Performance Missed ResponsesPre beverage-0 minutes14.97 PercentageStandard Deviation 17.36
Primary

Change in Continuous Performance Task Performance Number Incorrect

Continuous Performance Task- Number of incorrect responses

Time frame: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3-108 minutes

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in Continuous Performance Task Performance Number IncorrectPre beverage- 0 minutes0.44 PercentageStandard Deviation 0.51
PlaceboChange in Continuous Performance Task Performance Number IncorrectPost 1 beverage-30 minutes0.48 PercentageStandard Deviation 0.48
PlaceboChange in Continuous Performance Task Performance Number IncorrectPost 2 beverage- 60 minutes0.37 PercentageStandard Deviation 0.82
PlaceboChange in Continuous Performance Task Performance Number IncorrectPost 3 beverage- 108 minutes0.48 PercentageStandard Deviation 0.74
Caffeinated PlaceboChange in Continuous Performance Task Performance Number IncorrectPost 3 beverage- 108 minutes0.41 PercentageStandard Deviation 0.58
Caffeinated PlaceboChange in Continuous Performance Task Performance Number IncorrectPre beverage- 0 minutes0.49 PercentageStandard Deviation 0.79
Caffeinated PlaceboChange in Continuous Performance Task Performance Number IncorrectPost 2 beverage- 60 minutes0.51 PercentageStandard Deviation 1.13
Caffeinated PlaceboChange in Continuous Performance Task Performance Number IncorrectPost 1 beverage-30 minutes0.59 PercentageStandard Deviation 0.8
E+ShotsChange in Continuous Performance Task Performance Number IncorrectPost 3 beverage- 108 minutes0.37 PercentageStandard Deviation 0.63
E+ShotsChange in Continuous Performance Task Performance Number IncorrectPost 1 beverage-30 minutes0.45 PercentageStandard Deviation 0.71
E+ShotsChange in Continuous Performance Task Performance Number IncorrectPost 2 beverage- 60 minutes0.56 PercentageStandard Deviation 0.78
E+ShotsChange in Continuous Performance Task Performance Number IncorrectPre beverage- 0 minutes0.44 PercentageStandard Deviation 0.58
Primary

Change in Continuous Performance Task Performance Percent Correct

Continuous Performance Task- Percentage of correct responses Participants monitored a continuous series of letters (A-Z; Tahoma Regular font, size 20 pt) presented on the screen for 1000 ms. Participants were told to respond to the detection of the letter X only when it was preceded by the letter A by striking the left key on the key pad. The task was scored for percentage of target strings correctly detected, errors of omission (missed targets), average reaction time for correct detections, and the number of false alarms. The task lasted for two minutes and 48 targets were randomly presented

Time frame: pre beverage-0 minutes, post beverage 1- 30 minutes, post beverage 2- 68, post beverage 3-108 minutes

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in Continuous Performance Task Performance Percent CorrectPre beverage-0 minutes83.92 PercentageStandard Deviation 25.53
PlaceboChange in Continuous Performance Task Performance Percent CorrectPost 1 beverage-30 minutes77.79 PercentageStandard Deviation 25.49
PlaceboChange in Continuous Performance Task Performance Percent CorrectPost 2 beverage- 60 minutes79.07 PercentageStandard Deviation 23.83
PlaceboChange in Continuous Performance Task Performance Percent CorrectPost 3 beverage- 108 minutes79.07 PercentageStandard Deviation 23.83
Caffeinated PlaceboChange in Continuous Performance Task Performance Percent CorrectPost 3 beverage- 108 minutes86.40 PercentageStandard Deviation 16.47
Caffeinated PlaceboChange in Continuous Performance Task Performance Percent CorrectPre beverage-0 minutes80.46 PercentageStandard Deviation 29.5
Caffeinated PlaceboChange in Continuous Performance Task Performance Percent CorrectPost 2 beverage- 60 minutes82.95 PercentageStandard Deviation 27.88
Caffeinated PlaceboChange in Continuous Performance Task Performance Percent CorrectPost 1 beverage-30 minutes78.18 PercentageStandard Deviation 27.49
E+ShotsChange in Continuous Performance Task Performance Percent CorrectPost 3 beverage- 108 minutes85.56 PercentageStandard Deviation 14.23
E+ShotsChange in Continuous Performance Task Performance Percent CorrectPost 1 beverage-30 minutes83.32 PercentageStandard Deviation 21.01
E+ShotsChange in Continuous Performance Task Performance Percent CorrectPost 2 beverage- 60 minutes85.26 PercentageStandard Deviation 22.34
E+ShotsChange in Continuous Performance Task Performance Percent CorrectPre beverage-0 minutes84.93 PercentageStandard Deviation 17.69
Primary

Change in Continuous Performance Task Performance Reaction Time Correct Responses

Continuous Performance Task- reaction time for correct responses

Time frame: pre beverage-0 minutes, post beverage 1- 30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutes

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in Continuous Performance Task Performance Reaction Time Correct ResponsesPre beverage-0 minutes1441.63 msStandard Deviation 304.19
PlaceboChange in Continuous Performance Task Performance Reaction Time Correct ResponsesPost 1 beverage-30 minutes1515.54 msStandard Deviation 95.82
PlaceboChange in Continuous Performance Task Performance Reaction Time Correct ResponsesPost 2 beverage- 60 minutes1516.12 msStandard Deviation 111.05
PlaceboChange in Continuous Performance Task Performance Reaction Time Correct ResponsesPost 3 beverage- 108 minutes1498.28 msStandard Deviation 72.03
Caffeinated PlaceboChange in Continuous Performance Task Performance Reaction Time Correct ResponsesPost 3 beverage- 108 minutes1525.09 msStandard Deviation 82.97
Caffeinated PlaceboChange in Continuous Performance Task Performance Reaction Time Correct ResponsesPre beverage-0 minutes1475.20 msStandard Deviation 76.56
Caffeinated PlaceboChange in Continuous Performance Task Performance Reaction Time Correct ResponsesPost 2 beverage- 60 minutes1506.42 msStandard Deviation 91.91
Caffeinated PlaceboChange in Continuous Performance Task Performance Reaction Time Correct ResponsesPost 1 beverage-30 minutes157.81 msStandard Deviation 158.49
E+ShotsChange in Continuous Performance Task Performance Reaction Time Correct ResponsesPost 3 beverage- 108 minutes1474.22 msStandard Deviation 75.06
E+ShotsChange in Continuous Performance Task Performance Reaction Time Correct ResponsesPost 1 beverage-30 minutes1495.55 msStandard Deviation 85.77
E+ShotsChange in Continuous Performance Task Performance Reaction Time Correct ResponsesPost 2 beverage- 60 minutes1527.74 msStandard Deviation 122.18
E+ShotsChange in Continuous Performance Task Performance Reaction Time Correct ResponsesPre beverage-0 minutes1499.64 msStandard Deviation 102.77
Primary

Change in Fine Motor Task Performance

9-hole peg test- measured in seconds- The validated nine-hole peg test of finger dexterity was used to measure fine motor control. The 12 cm × 12 cm wooden pegboard contained nine holes and was placed on the desktop in front of the seated participant. There were nine 0.64 cm wide cylindrical pegs, were placed on the desktop outside of the container on the right side of the board and on the left side of the board for when the participant's right hand and left hand were tested, respectively. Participants were instructed to place one peg at a time into the pegboard holes until they were filled, and then remove each peg one at a time onto the desktop as fast as they could, first with their dominant hand and next with their non-dominant hand. Each test was performed twice.

Time frame: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in Fine Motor Task PerformancePre-beverage-0 minutes19.42 SecondsStandard Deviation 2.94
PlaceboChange in Fine Motor Task PerformancePost-beverage 1- 30 minutes18.80 SecondsStandard Deviation 2.45
PlaceboChange in Fine Motor Task PerformancePost-beverage 2-68 minutes18.70 SecondsStandard Deviation 2.76
PlaceboChange in Fine Motor Task PerformancePost-beverage 3-108 minutes18.54 SecondsStandard Deviation 2.94
Caffeinated PlaceboChange in Fine Motor Task PerformancePost-beverage 2-68 minutes18.22 SecondsStandard Deviation 2.86
Caffeinated PlaceboChange in Fine Motor Task PerformancePost-beverage 1- 30 minutes18.21 SecondsStandard Deviation 2.5
Caffeinated PlaceboChange in Fine Motor Task PerformancePre-beverage-0 minutes18.87 SecondsStandard Deviation 2.64
Caffeinated PlaceboChange in Fine Motor Task PerformancePost-beverage 3-108 minutes17.86 SecondsStandard Deviation 2.75
E+ShotsChange in Fine Motor Task PerformancePost-beverage 3-108 minutes18.17 SecondsStandard Deviation 2.93
E+ShotsChange in Fine Motor Task PerformancePost-beverage 2-68 minutes18.58 SecondsStandard Deviation 2.55
E+ShotsChange in Fine Motor Task PerformancePost-beverage 1- 30 minutes18.88 SecondsStandard Deviation 2.83
E+ShotsChange in Fine Motor Task PerformancePre-beverage-0 minutes19.27 SecondsStandard Deviation 2.65
E+Shot DiastolicChange in Fine Motor Task PerformancePre-beverage-0 minutes18.60 SecondsStandard Deviation 2.45
E+Shot DiastolicChange in Fine Motor Task PerformancePost-beverage 3-108 minutes17.50 SecondsStandard Deviation 2.2
E+Shot DiastolicChange in Fine Motor Task PerformancePost-beverage 1- 30 minutes17.93 SecondsStandard Deviation 2.09
E+Shot DiastolicChange in Fine Motor Task PerformancePost-beverage 2-68 minutes17.68 SecondsStandard Deviation 12.07
Caffeinated Placebo SystolicChange in Fine Motor Task PerformancePost-beverage 2-68 minutes18.78 SecondsStandard Deviation 3.38
Caffeinated Placebo SystolicChange in Fine Motor Task PerformancePost-beverage 3-108 minutes18.44 SecondsStandard Deviation 3.37
Caffeinated Placebo SystolicChange in Fine Motor Task PerformancePost-beverage 1- 30 minutes18.73 SecondsStandard Deviation 3.23
Caffeinated Placebo SystolicChange in Fine Motor Task PerformancePre-beverage-0 minutes19.31 SecondsStandard Deviation 3.4
Caffeinated Placebo DiastolicChange in Fine Motor Task PerformancePost-beverage 1- 30 minutes17.95 SecondsStandard Deviation 2.79
Caffeinated Placebo DiastolicChange in Fine Motor Task PerformancePost-beverage 2-68 minutes18.02 SecondsStandard Deviation 2.95
Caffeinated Placebo DiastolicChange in Fine Motor Task PerformancePost-beverage 3-108 minutes17.56 SecondsStandard Deviation 2.84
Caffeinated Placebo DiastolicChange in Fine Motor Task PerformancePre-beverage-0 minutes18.65 SecondsStandard Deviation 2.93
Primary

Change in Heart Rate

Heart rate- beats per minute

Time frame: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in Heart RatePre-beverage-0 minutes72.50 BPMStandard Deviation 13.86
PlaceboChange in Heart RatePost-beverage 2-68 minutes68.00 BPMStandard Deviation 13.86
PlaceboChange in Heart RatePost-beverage 1- 30 minutes70.10 BPMStandard Deviation 13.98
PlaceboChange in Heart RatePost-beverage 3-108 minutes66.83 BPMStandard Deviation 14.18
Caffeinated PlaceboChange in Heart RatePre-beverage-0 minutes70.13 BPMStandard Deviation 1.84
Caffeinated PlaceboChange in Heart RatePost-beverage 1- 30 minutes65.23 BPMStandard Deviation 11.31
Caffeinated PlaceboChange in Heart RatePost-beverage 2-68 minutes67.90 BPMStandard Deviation 14.51
Caffeinated PlaceboChange in Heart RatePost-beverage 3-108 minutes64.47 BPMStandard Deviation 13.64
E+ShotsChange in Heart RatePost-beverage 2-68 minutes67.10 BPMStandard Deviation 13.33
E+ShotsChange in Heart RatePre-beverage-0 minutes69.80 BPMStandard Deviation 13.99
E+ShotsChange in Heart RatePost-beverage 1- 30 minutes67.37 BPMStandard Deviation 12.35
E+ShotsChange in Heart RatePost-beverage 3-108 minutes63.83 BPMStandard Deviation 12.36
Primary

Change in POMS Anger

POMS Anger Scores range from 0-20 with higher scores indicating worse outcome

Time frame: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in POMS AngerPre-beverage-0 minutes5.27 Score on a scaleStandard Deviation 0.79
PlaceboChange in POMS AngerPost-beverage 1- 30 minutes5.30 Score on a scaleStandard Deviation 0.65
PlaceboChange in POMS AngerPost-beverage 2-68 minutes5.60 Score on a scaleStandard Deviation 1.04
PlaceboChange in POMS AngerPost-beverage 3-108 minutes5.31 Score on a scaleStandard Deviation 0.85
Caffeinated PlaceboChange in POMS AngerPost-beverage 3-108 minutes5.27 Score on a scaleStandard Deviation 0.53
Caffeinated PlaceboChange in POMS AngerPre-beverage-0 minutes5.47 Score on a scaleStandard Deviation 0.71
Caffeinated PlaceboChange in POMS AngerPost-beverage 2-68 minutes5.41 Score on a scaleStandard Deviation 1.35
Caffeinated PlaceboChange in POMS AngerPost-beverage 1- 30 minutes5.33 Score on a scaleStandard Deviation 0.71
E+ShotsChange in POMS AngerPost-beverage 3-108 minutes5.57 Score on a scaleStandard Deviation 1.2
E+ShotsChange in POMS AngerPost-beverage 1- 30 minutes5.53 Score on a scaleStandard Deviation 1.31
E+ShotsChange in POMS AngerPost-beverage 2-68 minutes5.47 Score on a scaleStandard Deviation 0.94
E+ShotsChange in POMS AngerPre-beverage-0 minutes5.90 Score on a scaleStandard Deviation 1.27
Primary

Change in POMS Anxiety

POMS Anxiety Scores range from 0-20 with higher scores indicating worse outcome

Time frame: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in POMS AnxietyPre-beverage-0 minutes5.43 Score on a scaleStandard Deviation 0.73
PlaceboChange in POMS AnxietyPost-beverage 1- 30 minutes5.40 Score on a scaleStandard Deviation 0.77
PlaceboChange in POMS AnxietyPost-beverage 2-68 minutes5.40 Score on a scaleStandard Deviation 0.72
PlaceboChange in POMS AnxietyPost-beverage 3-108 minutes5.52 Score on a scaleStandard Deviation 0.91
Caffeinated PlaceboChange in POMS AnxietyPost-beverage 3-108 minutes5.62 Score on a scaleStandard Deviation 1.1
Caffeinated PlaceboChange in POMS AnxietyPre-beverage-0 minutes5.63 Score on a scaleStandard Deviation 1.16
Caffeinated PlaceboChange in POMS AnxietyPost-beverage 2-68 minutes5.66 Score on a scaleStandard Deviation 1.52
Caffeinated PlaceboChange in POMS AnxietyPost-beverage 1- 30 minutes5.73 Score on a scaleStandard Deviation 1.34
E+ShotsChange in POMS AnxietyPost-beverage 3-108 minutes5.64 Score on a scaleStandard Deviation 1.03
E+ShotsChange in POMS AnxietyPost-beverage 1- 30 minutes5.77 Score on a scaleStandard Deviation 1.28
E+ShotsChange in POMS AnxietyPost-beverage 2-68 minutes5.87 Score on a scaleStandard Deviation 1.25
E+ShotsChange in POMS AnxietyPre-beverage-0 minutes5.60 Score on a scaleStandard Deviation 1.3
Primary

Change in POMS Confusion

POMS Anger Scores range from -4 to 16 with higher scores indicating worse outcome

Time frame: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minute

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in POMS ConfusionPre-beverage-0 minutes2.50 Score on a scaleStandard Deviation 1.25
PlaceboChange in POMS ConfusionPost-beverage 1- 30 minutes2.57 Score on a scaleStandard Deviation 1.17
PlaceboChange in POMS ConfusionPost-beverage 2-68 minutes2.50 Score on a scaleStandard Deviation 1.04
PlaceboChange in POMS ConfusionPost-beverage 3-108 minutes2.34 Score on a scaleStandard Deviation 1.05
Caffeinated PlaceboChange in POMS ConfusionPost-beverage 3-108 minutes2.58 Score on a scaleStandard Deviation 1.6
Caffeinated PlaceboChange in POMS ConfusionPre-beverage-0 minutes2.73 Score on a scaleStandard Deviation 1.57
Caffeinated PlaceboChange in POMS ConfusionPost-beverage 2-68 minutes2.59 Score on a scaleStandard Deviation 1.57
Caffeinated PlaceboChange in POMS ConfusionPost-beverage 1- 30 minutes2.33 Score on a scaleStandard Deviation 1.45
E+ShotsChange in POMS ConfusionPost-beverage 3-108 minutes2.29 Score on a scaleStandard Deviation 1.56
E+ShotsChange in POMS ConfusionPost-beverage 1- 30 minutes2.17 Score on a scaleStandard Deviation 1.21
E+ShotsChange in POMS ConfusionPost-beverage 2-68 minutes2.43 Score on a scaleStandard Deviation 1.43
E+ShotsChange in POMS ConfusionPre-beverage-0 minutes2.70 Score on a scaleStandard Deviation 1.54
Primary

Change in POMS Depression

POMS Depression Scores range from 0-20 with higher scores indicating worse outcome

Time frame: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in POMS DepressionPre-beverage- 0 minutes5.37 Score on a scaleStandard Deviation 1.07
PlaceboChange in POMS DepressionPost-beverage 1- 30 minutes5.43 Score on a scaleStandard Deviation 1.04
PlaceboChange in POMS DepressionPost-beverage 2-68 minutes5.30 Score on a scaleStandard Deviation 0.84
PlaceboChange in POMS DepressionPost-beverage 3-108 minutes5.28 Score on a scaleStandard Deviation 0.65
Caffeinated PlaceboChange in POMS DepressionPost-beverage 3-108 minutes5.31 Score on a scaleStandard Deviation 1.01
Caffeinated PlaceboChange in POMS DepressionPre-beverage- 0 minutes5.50 Score on a scaleStandard Deviation 1.41
Caffeinated PlaceboChange in POMS DepressionPost-beverage 2-68 minutes5.45 Score on a scaleStandard Deviation 1.27
Caffeinated PlaceboChange in POMS DepressionPost-beverage 1- 30 minutes5.50 Score on a scaleStandard Deviation 1.2
E+ShotsChange in POMS DepressionPost-beverage 3-108 minutes5.25 Score on a scaleStandard Deviation 0.59
E+ShotsChange in POMS DepressionPost-beverage 1- 30 minutes5.23 Score on a scaleStandard Deviation 0.63
E+ShotsChange in POMS DepressionPost-beverage 2-68 minutes5.20 Score on a scaleStandard Deviation 0.61
E+ShotsChange in POMS DepressionPre-beverage- 0 minutes5.30 Score on a scaleStandard Deviation 0.65
Primary

Change in POMS Fatigue

POMS Fatigue Scores range from 0-20with higher scores indicating worse outcome

Time frame: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in POMS FatiguePre-beverage- 0 minutes8.03 Score on a scaleStandard Deviation 2.94
PlaceboChange in POMS FatiguePost -beverage 1-30 minutes8.13 Score on a scaleStandard Deviation 2.98
PlaceboChange in POMS FatiguePost -beverage 2-68 minutes8.23 Score on a scaleStandard Deviation 2.62
PlaceboChange in POMS FatiguePost-beverage 3-108 minutes7.72 Score on a scaleStandard Deviation 2.55
Caffeinated PlaceboChange in POMS FatiguePost-beverage 3-108 minutes7.77 Score on a scaleStandard Deviation 3.15
Caffeinated PlaceboChange in POMS FatiguePre-beverage- 0 minutes8.00 Score on a scaleStandard Deviation 2.89
Caffeinated PlaceboChange in POMS FatiguePost -beverage 2-68 minutes7.66 Score on a scaleStandard Deviation 3.27
Caffeinated PlaceboChange in POMS FatiguePost -beverage 1-30 minutes7.07 Score on a scaleStandard Deviation 2.48
E+ShotsChange in POMS FatiguePost-beverage 3-108 minutes8.07 Score on a scaleStandard Deviation 3.22
E+ShotsChange in POMS FatiguePost -beverage 1-30 minutes7.67 Score on a scaleStandard Deviation 2.94
E+ShotsChange in POMS FatiguePost -beverage 2-68 minutes7.57 Score on a scaleStandard Deviation 2.81
E+ShotsChange in POMS FatiguePre-beverage- 0 minutes8.17 Score on a scaleStandard Deviation 2.81
Primary

Change in POMS Vigor

POMS Vigor, Scores range from 0-20 with higher scores indicating improved outcome

Time frame: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in POMS VigorPre-beverage-0 minutes9.03 score on a scaleStandard Deviation 4.63
PlaceboChange in POMS VigorPost-beverage 1- 30 minutes9.03 score on a scaleStandard Deviation 4.17
PlaceboChange in POMS VigorPost-beverage 2-68 minutes9.33 score on a scaleStandard Deviation 4.33
PlaceboChange in POMS VigorPost-beverage 3-108 minutes9.38 score on a scaleStandard Deviation 4.59
Caffeinated PlaceboChange in POMS VigorPost-beverage 3-108 minutes9.89 score on a scaleStandard Deviation 5.22
Caffeinated PlaceboChange in POMS VigorPre-beverage-0 minutes8.93 score on a scaleStandard Deviation 4.6
Caffeinated PlaceboChange in POMS VigorPost-beverage 2-68 minutes9.87 score on a scaleStandard Deviation 4.38
Caffeinated PlaceboChange in POMS VigorPost-beverage 1- 30 minutes10.13 score on a scaleStandard Deviation 3.91
E+ShotsChange in POMS VigorPost-beverage 3-108 minutes10.15 score on a scaleStandard Deviation 4.54
E+ShotsChange in POMS VigorPost-beverage 1- 30 minutes9.67 score on a scaleStandard Deviation 4.03
E+ShotsChange in POMS VigorPost-beverage 2-68 minutes9.76 score on a scaleStandard Deviation 4.27
E+ShotsChange in POMS VigorPre-beverage-0 minutes8.80 score on a scaleStandard Deviation 4.6
Primary

Change in Rapid Visual Input Processing Task Performance Primary Task Incorrect Responses

Rapid Visual Input Processing task- Primary task- incorrect responses

Time frame: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutes

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in Rapid Visual Input Processing Task Performance Primary Task Incorrect ResponsesPre beverage-0 minutes8.70 PercentageStandard Deviation 9.57
PlaceboChange in Rapid Visual Input Processing Task Performance Primary Task Incorrect ResponsesPost 1 beverage-30 minutes9.55 PercentageStandard Deviation 8.72
PlaceboChange in Rapid Visual Input Processing Task Performance Primary Task Incorrect ResponsesPost 2 beverage- 60 minutes7.33 PercentageStandard Deviation 8.27
PlaceboChange in Rapid Visual Input Processing Task Performance Primary Task Incorrect ResponsesPost 3 beverage- 108 minutes7.33 PercentageStandard Deviation 8.27
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Primary Task Incorrect ResponsesPost 3 beverage- 108 minutes7.27 PercentageStandard Deviation 5.79
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Primary Task Incorrect ResponsesPre beverage-0 minutes9.40 PercentageStandard Deviation 9.64
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Primary Task Incorrect ResponsesPost 2 beverage- 60 minutes6.47 PercentageStandard Deviation 8.96
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Primary Task Incorrect ResponsesPost 1 beverage-30 minutes6.58 PercentageStandard Deviation 8.34
E+ShotsChange in Rapid Visual Input Processing Task Performance Primary Task Incorrect ResponsesPost 3 beverage- 108 minutes7.54 PercentageStandard Deviation 7.88
E+ShotsChange in Rapid Visual Input Processing Task Performance Primary Task Incorrect ResponsesPost 1 beverage-30 minutes6.50 PercentageStandard Deviation 7.3
E+ShotsChange in Rapid Visual Input Processing Task Performance Primary Task Incorrect ResponsesPost 2 beverage- 60 minutes9.88 PercentageStandard Deviation 10.5
E+ShotsChange in Rapid Visual Input Processing Task Performance Primary Task Incorrect ResponsesPre beverage-0 minutes8.65 PercentageStandard Deviation 10.28
Primary

Change in Rapid Visual Input Processing Task Performance Primary Task Percentage Correct

Rapid Visual Input Processing task- Primary task- percentage correct

Time frame: pre beverage- 0 minutes, post beverage 1- 30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutes

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in Rapid Visual Input Processing Task Performance Primary Task Percentage CorrectPre beverage-0 minutese59.45 PercentageStandard Deviation 24.98
PlaceboChange in Rapid Visual Input Processing Task Performance Primary Task Percentage CorrectPost 1 beverage-30 minutes61.79 PercentageStandard Deviation 25.86
PlaceboChange in Rapid Visual Input Processing Task Performance Primary Task Percentage CorrectPost 2 beverage- 60 minutes65.18 PercentageStandard Deviation 20.86
PlaceboChange in Rapid Visual Input Processing Task Performance Primary Task Percentage CorrectPost 3 beverage- 108 minutes62.52 PercentageStandard Deviation 26.73
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Primary Task Percentage CorrectPost 3 beverage- 108 minutes64.65 PercentageStandard Deviation 20.36
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Primary Task Percentage CorrectPre beverage-0 minutese60.78 PercentageStandard Deviation 26.18
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Primary Task Percentage CorrectPost 2 beverage- 60 minutes70.27 PercentageStandard Deviation 24.57
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Primary Task Percentage CorrectPost 1 beverage-30 minutes67.16 PercentageStandard Deviation 23.99
E+ShotsChange in Rapid Visual Input Processing Task Performance Primary Task Percentage CorrectPost 3 beverage- 108 minutes71.38 PercentageStandard Deviation 19.06
E+ShotsChange in Rapid Visual Input Processing Task Performance Primary Task Percentage CorrectPost 1 beverage-30 minutes64.70 PercentageStandard Deviation 25.18
E+ShotsChange in Rapid Visual Input Processing Task Performance Primary Task Percentage CorrectPost 2 beverage- 60 minutes67.13 PercentageStandard Deviation 24.75
E+ShotsChange in Rapid Visual Input Processing Task Performance Primary Task Percentage CorrectPre beverage-0 minutese57.18 PercentageStandard Deviation 27.66
Primary

Change in Rapid Visual Input Processing Task Performance Primary Task Percent Missed

Rapid Visual Input Processing task- Primary task- percentage missed

Time frame: pre beverage-0 minutes, post beverage 1- 30 minutes, post beverage 2-68 minutes, post beverage 3- 108 minutes

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in Rapid Visual Input Processing Task Performance Primary Task Percent MissedPre beverage-0 minutes31.85 PercentageStandard Deviation 22.01
PlaceboChange in Rapid Visual Input Processing Task Performance Primary Task Percent MissedPost 1 beverage-30 minutes28.65 PercentageStandard Deviation 24
PlaceboChange in Rapid Visual Input Processing Task Performance Primary Task Percent MissedPost 2 beverage- 60 minutes27.43 PercentageStandard Deviation 19.29
PlaceboChange in Rapid Visual Input Processing Task Performance Primary Task Percent MissedPost 3 beverage- 108 minutes30.73 PercentageStandard Deviation 26
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Primary Task Percent MissedPost 3 beverage- 108 minutes27.90 PercentageStandard Deviation 19.7
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Primary Task Percent MissedPre beverage-0 minutes29.82 PercentageStandard Deviation 20.67
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Primary Task Percent MissedPost 2 beverage- 60 minutes22.82 PercentageStandard Deviation 20.58
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Primary Task Percent MissedPost 1 beverage-30 minutes39.62 PercentageStandard Deviation 25.39
E+ShotsChange in Rapid Visual Input Processing Task Performance Primary Task Percent MissedPost 3 beverage- 108 minutes20.69 PercentageStandard Deviation 17
E+ShotsChange in Rapid Visual Input Processing Task Performance Primary Task Percent MissedPost 1 beverage-30 minutes28.85 PercentageStandard Deviation 25.07
E+ShotsChange in Rapid Visual Input Processing Task Performance Primary Task Percent MissedPost 2 beverage- 60 minutes20.51 PercentageStandard Deviation 16.77
E+ShotsChange in Rapid Visual Input Processing Task Performance Primary Task Percent MissedPre beverage-0 minutes34.13 PercentageStandard Deviation 24.3
Primary

Change in Rapid Visual Input Processing Task Performance Primary Task Reaction Time for Percent Correct

Rapid Visual Input Processing task- Primary task- reaction time for percent correct

Time frame: pre beverage- 0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutes

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in Rapid Visual Input Processing Task Performance Primary Task Reaction Time for Percent CorrectPre beverage-0 minutes777.76 msStandard Deviation 93.09
PlaceboChange in Rapid Visual Input Processing Task Performance Primary Task Reaction Time for Percent CorrectPost 1 beverage-30 minutes761.51 msStandard Deviation 74.29
PlaceboChange in Rapid Visual Input Processing Task Performance Primary Task Reaction Time for Percent CorrectPost 2 beverage- 60 minutes791.83 msStandard Deviation 55.05
PlaceboChange in Rapid Visual Input Processing Task Performance Primary Task Reaction Time for Percent CorrectPost 3 beverage- 108 minutes770.84 msStandard Deviation 71.41
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Primary Task Reaction Time for Percent CorrectPost 3 beverage- 108 minutes736.22 msStandard Deviation 49.3
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Primary Task Reaction Time for Percent CorrectPre beverage-0 minutes782.84 msStandard Deviation 99.82
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Primary Task Reaction Time for Percent CorrectPost 2 beverage- 60 minutes752.33 msStandard Deviation 85.85
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Primary Task Reaction Time for Percent CorrectPost 1 beverage-30 minutes774.57 msStandard Deviation 71.21
E+ShotsChange in Rapid Visual Input Processing Task Performance Primary Task Reaction Time for Percent CorrectPost 3 beverage- 108 minutes727.96 msStandard Deviation 79.6
E+ShotsChange in Rapid Visual Input Processing Task Performance Primary Task Reaction Time for Percent CorrectPost 1 beverage-30 minutes773.95 msStandard Deviation 75.76
E+ShotsChange in Rapid Visual Input Processing Task Performance Primary Task Reaction Time for Percent CorrectPost 2 beverage- 60 minutes73.10 msStandard Deviation 76.58
E+ShotsChange in Rapid Visual Input Processing Task Performance Primary Task Reaction Time for Percent CorrectPre beverage-0 minutes786.74 msStandard Deviation 121.13
Primary

Change in Rapid Visual Input Processing Task Performance Secondary Task Incorrect Responses

Rapid Visual Input Processing task- Secondary task- incorrect responses

Time frame: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3-108 minutes

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in Rapid Visual Input Processing Task Performance Secondary Task Incorrect ResponsesPre beverage-0 minutes1.36 PercentageStandard Deviation 3.19
PlaceboChange in Rapid Visual Input Processing Task Performance Secondary Task Incorrect ResponsesPost 1 beverage-30 minutes0.42 PercentageStandard Deviation 1.86
PlaceboChange in Rapid Visual Input Processing Task Performance Secondary Task Incorrect ResponsesPost 2 beverage- 60 minutes0.46 PercentageStandard Deviation 1.96
PlaceboChange in Rapid Visual Input Processing Task Performance Secondary Task Incorrect ResponsesPost 3 beverage- 108 minutes0.52 PercentageStandard Deviation 2.08
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Secondary Task Incorrect ResponsesPost 3 beverage- 108 minutes1.04 PercentageStandard Deviation 2.85
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Secondary Task Incorrect ResponsesPre beverage-0 minutes2.64 PercentageStandard Deviation 5.37
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Secondary Task Incorrect ResponsesPost 2 beverage- 60 minutes0.83 PercentageStandard Deviation 2.56
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Secondary Task Incorrect ResponsesPost 1 beverage-30 minutes0.00 PercentageStandard Deviation 0
E+ShotsChange in Rapid Visual Input Processing Task Performance Secondary Task Incorrect ResponsesPost 3 beverage- 108 minutes0.38 PercentageStandard Deviation 1.78
E+ShotsChange in Rapid Visual Input Processing Task Performance Secondary Task Incorrect ResponsesPost 1 beverage-30 minutes0.00 PercentageStandard Deviation 0
E+ShotsChange in Rapid Visual Input Processing Task Performance Secondary Task Incorrect ResponsesPost 2 beverage- 60 minutes0.36 PercentageStandard Deviation 1.71
E+ShotsChange in Rapid Visual Input Processing Task Performance Secondary Task Incorrect ResponsesPre beverage-0 minutes1.09 PercentageStandard Deviation 3.81
Primary

Change in Rapid Visual Input Processing Task Performance Secondary Task Percentage Missed Responses

Rapid Visual Input Processing task- Secondary task- percentage missed responses

Time frame: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutes

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in Rapid Visual Input Processing Task Performance Secondary Task Percentage Missed ResponsesPre beverage-0 minutes39.85 PercentageStandard Deviation 20.24
PlaceboChange in Rapid Visual Input Processing Task Performance Secondary Task Percentage Missed ResponsesPost 1 beverage-30 minutes44.42 PercentageStandard Deviation 19.59
PlaceboChange in Rapid Visual Input Processing Task Performance Secondary Task Percentage Missed ResponsesPost 2 beverage- 60 minutes45.17 PercentageStandard Deviation 24.55
PlaceboChange in Rapid Visual Input Processing Task Performance Secondary Task Percentage Missed ResponsesPost 3 beverage- 108 minutes38.28 PercentageStandard Deviation 24.45
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Secondary Task Percentage Missed ResponsesPost 3 beverage- 108 minutes37.35 PercentageStandard Deviation 22.83
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Secondary Task Percentage Missed ResponsesPre beverage-0 minutes42.08 PercentageStandard Deviation 22.55
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Secondary Task Percentage Missed ResponsesPost 2 beverage- 60 minutes0.42 PercentageStandard Deviation 29.88
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Secondary Task Percentage Missed ResponsesPost 1 beverage-30 minutes39.62 PercentageStandard Deviation 25.39
E+ShotsChange in Rapid Visual Input Processing Task Performance Secondary Task Percentage Missed ResponsesPost 3 beverage- 108 minutes35.63 PercentageStandard Deviation 24.38
E+ShotsChange in Rapid Visual Input Processing Task Performance Secondary Task Percentage Missed ResponsesPost 1 beverage-30 minutes41.07 PercentageStandard Deviation 27.25
E+ShotsChange in Rapid Visual Input Processing Task Performance Secondary Task Percentage Missed ResponsesPost 2 beverage- 60 minutes41.07 PercentageStandard Deviation 28.36
E+ShotsChange in Rapid Visual Input Processing Task Performance Secondary Task Percentage Missed ResponsesPre beverage-0 minutes43.64 PercentageStandard Deviation 24.28
Primary

Change in Rapid Visual Input Processing Task Performance Secondary Task Percent Correct

Rapid Visual Input Processing task- Secondary task- percentage correct

Time frame: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutes

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in Rapid Visual Input Processing Task Performance Secondary Task Percent CorrectPre beverage-0 minutes58.75 PercentageStandard Deviation 21.45
PlaceboChange in Rapid Visual Input Processing Task Performance Secondary Task Percent CorrectPost 1 beverage-30 minutes54.75 PercentageStandard Deviation 19.69
PlaceboChange in Rapid Visual Input Processing Task Performance Secondary Task Percent CorrectPost 2 beverage- 60 minutes54.32 PercentageStandard Deviation 24.46
PlaceboChange in Rapid Visual Input Processing Task Performance Secondary Task Percent CorrectPost 3 beverage- 108 minutes61.11 PercentageStandard Deviation 24.75
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Secondary Task Percent CorrectPost 3 beverage- 108 minutes61.56 PercentageStandard Deviation 23.46
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Secondary Task Percent CorrectPre beverage-0 minutes55.24 PercentageStandard Deviation 23.1
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Secondary Task Percent CorrectPost 2 beverage- 60 minutes57.05 PercentageStandard Deviation 30.08
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Secondary Task Percent CorrectPost 1 beverage-30 minutes59.98 PercentageStandard Deviation 25.75
E+ShotsChange in Rapid Visual Input Processing Task Performance Secondary Task Percent CorrectPost 3 beverage- 108 minutes63.98 PercentageStandard Deviation 24.26
E+ShotsChange in Rapid Visual Input Processing Task Performance Secondary Task Percent CorrectPost 1 beverage-30 minutes58.93 PercentageStandard Deviation 27.25
E+ShotsChange in Rapid Visual Input Processing Task Performance Secondary Task Percent CorrectPost 2 beverage- 60 minutes58.56 PercentageStandard Deviation 28.2
E+ShotsChange in Rapid Visual Input Processing Task Performance Secondary Task Percent CorrectPre beverage-0 minutes55.28 PercentageStandard Deviation 58.93
Primary

Change in Rapid Visual Input Processing Task Performance Secondary Task Reaction Time for Correct Responses

Rapid Visual Input Processing task- Secondary task- reaction time for correct responses

Time frame: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutes

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in Rapid Visual Input Processing Task Performance Secondary Task Reaction Time for Correct ResponsesPre beverage-0 minutes610.31 msStandard Deviation 124.82
PlaceboChange in Rapid Visual Input Processing Task Performance Secondary Task Reaction Time for Correct ResponsesPost 1 beverage-30 minutes627.79 msStandard Deviation 59.08
PlaceboChange in Rapid Visual Input Processing Task Performance Secondary Task Reaction Time for Correct ResponsesPost 2 beverage- 60 minutes628.47 msStandard Deviation 108.98
PlaceboChange in Rapid Visual Input Processing Task Performance Secondary Task Reaction Time for Correct ResponsesPost 3 beverage- 108 minutes649.46 msStandard Deviation 90.9
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Secondary Task Reaction Time for Correct ResponsesPost 3 beverage- 108 minutes633.80 msStandard Deviation 67.24
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Secondary Task Reaction Time for Correct ResponsesPre beverage-0 minutes66.66 msStandard Deviation 98.86
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Secondary Task Reaction Time for Correct ResponsesPost 2 beverage- 60 minutes634.83 msStandard Deviation 102.15
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Secondary Task Reaction Time for Correct ResponsesPost 1 beverage-30 minutes601.89 msStandard Deviation 76.14
E+ShotsChange in Rapid Visual Input Processing Task Performance Secondary Task Reaction Time for Correct ResponsesPost 3 beverage- 108 minutes598.90 msStandard Deviation 92
E+ShotsChange in Rapid Visual Input Processing Task Performance Secondary Task Reaction Time for Correct ResponsesPost 1 beverage-30 minutes604.52 msStandard Deviation 87.25
E+ShotsChange in Rapid Visual Input Processing Task Performance Secondary Task Reaction Time for Correct ResponsesPost 2 beverage- 60 minutes621.75 msStandard Deviation 129.66
E+ShotsChange in Rapid Visual Input Processing Task Performance Secondary Task Reaction Time for Correct ResponsesPre beverage-0 minutes612.76 msStandard Deviation 65.11
Primary

Change in Rapid Visual Input Processing Task Performance Tertiary Task Number of Incorrect Responses

Rapid Visual Input Processing task- Tertiary task- number of incorrect responses

Time frame: pre beverage-0 minutes, post beverage 1- 30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutes

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in Rapid Visual Input Processing Task Performance Tertiary Task Number of Incorrect ResponsesPost 2 beverage- 60 minutes3.05 PercentageStandard Deviation 7.95
PlaceboChange in Rapid Visual Input Processing Task Performance Tertiary Task Number of Incorrect ResponsesPre beverage-0 minutes4.68 PercentageStandard Deviation 7.09
PlaceboChange in Rapid Visual Input Processing Task Performance Tertiary Task Number of Incorrect ResponsesPost 3 beverage- 108 minutes2.92 PercentageStandard Deviation 5.03
PlaceboChange in Rapid Visual Input Processing Task Performance Tertiary Task Number of Incorrect ResponsesPost 1 beverage-30 minutes2.57 PercentageStandard Deviation 3.97
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Tertiary Task Number of Incorrect ResponsesPost 2 beverage- 60 minutes1.62 PercentageStandard Deviation 3.42
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Tertiary Task Number of Incorrect ResponsesPost 1 beverage-30 minutes1.81 PercentageStandard Deviation 4.35
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Tertiary Task Number of Incorrect ResponsesPost 3 beverage- 108 minutes1.94 PercentageStandard Deviation 3.61
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Tertiary Task Number of Incorrect ResponsesPre beverage-0 minutes3.10 PercentageStandard Deviation 5.36
E+ShotsChange in Rapid Visual Input Processing Task Performance Tertiary Task Number of Incorrect ResponsesPost 3 beverage- 108 minutes1.52 PercentageStandard Deviation 4.18
E+ShotsChange in Rapid Visual Input Processing Task Performance Tertiary Task Number of Incorrect ResponsesPre beverage-0 minutes2.40 PercentageStandard Deviation 4.55
E+ShotsChange in Rapid Visual Input Processing Task Performance Tertiary Task Number of Incorrect ResponsesPost 1 beverage-30 minutes2.98 PercentageStandard Deviation 8.17
E+ShotsChange in Rapid Visual Input Processing Task Performance Tertiary Task Number of Incorrect ResponsesPost 2 beverage- 60 minutes3.07 PercentageStandard Deviation 4.89
Primary

Change in Rapid Visual Input Processing Task Performance Tertiary Task Percentage Correct Responses

Rapid Visual Input Processing task- Tertiary task- percentage correct responses

Time frame: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutes

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in Rapid Visual Input Processing Task Performance Tertiary Task Percentage Correct ResponsesPre beverage-0 minutes83.76 PercentageStandard Deviation 19.05
PlaceboChange in Rapid Visual Input Processing Task Performance Tertiary Task Percentage Correct ResponsesPost 1 beverage-30 minutes84.05 PercentageStandard Deviation 15.79
PlaceboChange in Rapid Visual Input Processing Task Performance Tertiary Task Percentage Correct ResponsesPost 2 beverage- 60 minutes85.57 PercentageStandard Deviation 13.61
PlaceboChange in Rapid Visual Input Processing Task Performance Tertiary Task Percentage Correct ResponsesPost 3 beverage- 108 minutes88.09 PercentageStandard Deviation 12.85
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Tertiary Task Percentage Correct ResponsesPost 3 beverage- 108 minutes88.73 PercentageStandard Deviation 14.23
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Tertiary Task Percentage Correct ResponsesPre beverage-0 minutes88.89 PercentageStandard Deviation 12.38
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Tertiary Task Percentage Correct ResponsesPost 2 beverage- 60 minutes87.77 PercentageStandard Deviation 16.48
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Tertiary Task Percentage Correct ResponsesPost 1 beverage-30 minutes88.21 PercentageStandard Deviation 14.81
E+ShotsChange in Rapid Visual Input Processing Task Performance Tertiary Task Percentage Correct ResponsesPost 3 beverage- 108 minutes89.59 PercentageStandard Deviation 10.67
E+ShotsChange in Rapid Visual Input Processing Task Performance Tertiary Task Percentage Correct ResponsesPost 1 beverage-30 minutes90.61 PercentageStandard Deviation 8.1
E+ShotsChange in Rapid Visual Input Processing Task Performance Tertiary Task Percentage Correct ResponsesPost 2 beverage- 60 minutes85.90 PercentageStandard Deviation 16.46
E+ShotsChange in Rapid Visual Input Processing Task Performance Tertiary Task Percentage Correct ResponsesPre beverage-0 minutes86.45 PercentageStandard Deviation 11.74
Primary

Change in Rapid Visual Input Processing Task Performance- Tertiary Task Percent Missed Responses

Rapid Visual Input Processing task- Tertiary task- percentage missed responses

Time frame: pre beverage-0 minute, post beverage-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutes

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in Rapid Visual Input Processing Task Performance- Tertiary Task Percent Missed ResponsesPre beverage-0 minutes12.56 PercentageStandard Deviation 16.49
PlaceboChange in Rapid Visual Input Processing Task Performance- Tertiary Task Percent Missed ResponsesPost 1 beverage-30 minutes15.32 PercentageStandard Deviation 15.85
PlaceboChange in Rapid Visual Input Processing Task Performance- Tertiary Task Percent Missed ResponsesPost 2 beverage- 60 minutes11.47 PercentageStandard Deviation 11.41
PlaceboChange in Rapid Visual Input Processing Task Performance- Tertiary Task Percent Missed ResponsesPost 3 beverage- 108 minutes10.16 PercentageStandard Deviation 13.55
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance- Tertiary Task Percent Missed ResponsesPost 3 beverage- 108 minutes8.42 PercentageStandard Deviation 13
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance- Tertiary Task Percent Missed ResponsesPre beverage-0 minutes9.55 PercentageStandard Deviation 11.72
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance- Tertiary Task Percent Missed ResponsesPost 2 beverage- 60 minutes11.40 PercentageStandard Deviation 16.71
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance- Tertiary Task Percent Missed ResponsesPost 1 beverage-30 minutes10.30 PercentageStandard Deviation 14.14
E+ShotsChange in Rapid Visual Input Processing Task Performance- Tertiary Task Percent Missed ResponsesPost 3 beverage- 108 minutes9.41 PercentageStandard Deviation 10.6
E+ShotsChange in Rapid Visual Input Processing Task Performance- Tertiary Task Percent Missed ResponsesPost 1 beverage-30 minutes9.20 PercentageStandard Deviation 11.32
E+ShotsChange in Rapid Visual Input Processing Task Performance- Tertiary Task Percent Missed ResponsesPost 2 beverage- 60 minutes12.43 PercentageStandard Deviation 15.63
E+ShotsChange in Rapid Visual Input Processing Task Performance- Tertiary Task Percent Missed ResponsesPre beverage-0 minutes11.18 PercentageStandard Deviation 10.17
Primary

Change in Rapid Visual Input Processing Task Performance Tertiary Task Reaction Time for Correct Responses

Rapid Visual Input Processing task- Tertiary task- reaction time for correct responses

Time frame: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutes

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in Rapid Visual Input Processing Task Performance Tertiary Task Reaction Time for Correct ResponsesPre beverage-0 minutes749.10 msStandard Deviation 56.08
PlaceboChange in Rapid Visual Input Processing Task Performance Tertiary Task Reaction Time for Correct ResponsesPost 1 beverage-30 minutes745.10 msStandard Deviation 61.1
PlaceboChange in Rapid Visual Input Processing Task Performance Tertiary Task Reaction Time for Correct ResponsesPost 2 beverage- 60 minutes738.66 msStandard Deviation 56
PlaceboChange in Rapid Visual Input Processing Task Performance Tertiary Task Reaction Time for Correct ResponsesPost 3 beverage- 108 minutes717.86 msStandard Deviation 40.95
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Tertiary Task Reaction Time for Correct ResponsesPost 3 beverage- 108 minutes737.23 msStandard Deviation 49.38
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Tertiary Task Reaction Time for Correct ResponsesPre beverage-0 minutes761.78 msStandard Deviation 60.5
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Tertiary Task Reaction Time for Correct ResponsesPost 2 beverage- 60 minutes728.52 msStandard Deviation 46.69
Caffeinated PlaceboChange in Rapid Visual Input Processing Task Performance Tertiary Task Reaction Time for Correct ResponsesPost 1 beverage-30 minutes731.21 msStandard Deviation 44.1
E+ShotsChange in Rapid Visual Input Processing Task Performance Tertiary Task Reaction Time for Correct ResponsesPost 3 beverage- 108 minutes739.53 msStandard Deviation 58.21
E+ShotsChange in Rapid Visual Input Processing Task Performance Tertiary Task Reaction Time for Correct ResponsesPost 1 beverage-30 minutes746.90 msStandard Deviation 53.46
E+ShotsChange in Rapid Visual Input Processing Task Performance Tertiary Task Reaction Time for Correct ResponsesPost 2 beverage- 60 minutes751.04 msStandard Deviation 55.61
E+ShotsChange in Rapid Visual Input Processing Task Performance Tertiary Task Reaction Time for Correct ResponsesPre beverage-0 minutes752.61 msStandard Deviation 61.42
Primary

Change in Serial Subtraction 3 Task Performance

Serial subtraction 3- Number of attempts

Time frame: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in Serial Subtraction 3 Task PerformancePre-beverage-0 minutes46.23 attemptsStandard Deviation 16.18
PlaceboChange in Serial Subtraction 3 Task PerformancePost-beverage 1- 30 minutes52.77 attemptsStandard Deviation 15.84
PlaceboChange in Serial Subtraction 3 Task PerformancePost-beverage 2-68 minutes54.47 attemptsStandard Deviation 16.11
PlaceboChange in Serial Subtraction 3 Task PerformancePost-beverage 3-108 minutes56.10 attemptsStandard Deviation 16.01
Caffeinated PlaceboChange in Serial Subtraction 3 Task PerformancePost-beverage 3-108 minutes57.21 attemptsStandard Deviation 15.98
Caffeinated PlaceboChange in Serial Subtraction 3 Task PerformancePre-beverage-0 minutes48.20 attemptsStandard Deviation 14.59
Caffeinated PlaceboChange in Serial Subtraction 3 Task PerformancePost-beverage 2-68 minutes53.50 attemptsStandard Deviation 15.36
Caffeinated PlaceboChange in Serial Subtraction 3 Task PerformancePost-beverage 1- 30 minutes50.63 attemptsStandard Deviation 15.9
E+ShotsChange in Serial Subtraction 3 Task PerformancePost-beverage 3-108 minutes55.33 attemptsStandard Deviation 16.6
E+ShotsChange in Serial Subtraction 3 Task PerformancePost-beverage 1- 30 minutes54.86 attemptsStandard Deviation 15.92
E+ShotsChange in Serial Subtraction 3 Task PerformancePost-beverage 2-68 minutes54.34 attemptsStandard Deviation 16.32
E+ShotsChange in Serial Subtraction 3 Task PerformancePre-beverage-0 minutes46.27 attemptsStandard Deviation 16.45
Primary

Change in Serial Subtraction 3 Task Performance

Serial subtraction 3- Percentage correct

Time frame: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in Serial Subtraction 3 Task PerformancePre-beverage-0 minutes96.35 PercentageStandard Deviation 3.98
PlaceboChange in Serial Subtraction 3 Task PerformancePost-beverage 1- 30 minutes96.98 PercentageStandard Deviation 3.07
PlaceboChange in Serial Subtraction 3 Task PerformancePost-beverage 2-68 minutes96.21 PercentageStandard Deviation 3.18
PlaceboChange in Serial Subtraction 3 Task PerformancePost-beverage 3-108 minutes95.09 PercentageStandard Deviation 4.48
Caffeinated PlaceboChange in Serial Subtraction 3 Task PerformancePost-beverage 3-108 minutes93.96 PercentageStandard Deviation 8.89
Caffeinated PlaceboChange in Serial Subtraction 3 Task PerformancePre-beverage-0 minutes95.69 PercentageStandard Deviation 4.23
Caffeinated PlaceboChange in Serial Subtraction 3 Task PerformancePost-beverage 2-68 minutes95.57 PercentageStandard Deviation 3.38
Caffeinated PlaceboChange in Serial Subtraction 3 Task PerformancePost-beverage 1- 30 minutes95.76 PercentageStandard Deviation 3.69
E+ShotsChange in Serial Subtraction 3 Task PerformancePost-beverage 3-108 minutes93.79 PercentageStandard Deviation 6.63
E+ShotsChange in Serial Subtraction 3 Task PerformancePost-beverage 1- 30 minutes96.22 PercentageStandard Deviation 3.88
E+ShotsChange in Serial Subtraction 3 Task PerformancePost-beverage 2-68 minutes92.78 PercentageStandard Deviation 7.83
E+ShotsChange in Serial Subtraction 3 Task PerformancePre-beverage-0 minutes94.43 PercentageStandard Deviation 6.85
Primary

Change in Serial Subtraction 3 Task Performance

Serial subtraction 3- Number correct

Time frame: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in Serial Subtraction 3 Task PerformancePre-beverage-0 minutes44.80 correct attemptsStandard Deviation 16.24
PlaceboChange in Serial Subtraction 3 Task PerformancePost-beverage 1- 30 minutes51.17 correct attemptsStandard Deviation 15.57
PlaceboChange in Serial Subtraction 3 Task PerformancePost-beverage 2-68 minutes52.63 correct attemptsStandard Deviation 16.26
PlaceboChange in Serial Subtraction 3 Task PerformancePost-beverage 3-108 minutes53.38 correct attemptsStandard Deviation 16.15
Caffeinated PlaceboChange in Serial Subtraction 3 Task PerformancePost-beverage 3-108 minutes54.59 correct attemptsStandard Deviation 16.9
Caffeinated PlaceboChange in Serial Subtraction 3 Task PerformancePre-beverage-0 minutes46.27 correct attemptsStandard Deviation 14.7
Caffeinated PlaceboChange in Serial Subtraction 3 Task PerformancePost-beverage 2-68 minutes51.37 correct attemptsStandard Deviation 15.54
Caffeinated PlaceboChange in Serial Subtraction 3 Task PerformancePost-beverage 1- 30 minutes48.70 correct attemptsStandard Deviation 16.08
E+ShotsChange in Serial Subtraction 3 Task PerformancePost-beverage 3-108 minutes52.17 correct attemptsStandard Deviation 17.85
E+ShotsChange in Serial Subtraction 3 Task PerformancePost-beverage 1- 30 minutes52.97 correct attemptsStandard Deviation 16.16
E+ShotsChange in Serial Subtraction 3 Task PerformancePost-beverage 2-68 minutes51.82 correct attemptsStandard Deviation 16.91
E+ShotsChange in Serial Subtraction 3 Task PerformancePre-beverage-0 minutes44.23 correct attemptsStandard Deviation 17.08
Primary

Change in Serial Subtraction 7 Task Performance

Serial subtraction 7- Number of attempts

Time frame: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in Serial Subtraction 7 Task PerformancePre-beverage-0 minutes26.53 attemptsStandard Deviation 10.19
PlaceboChange in Serial Subtraction 7 Task PerformancePost-beverage 1- 30 minutes29.38 attemptsStandard Deviation 10.71
PlaceboChange in Serial Subtraction 7 Task PerformancePost-beverage 2-68 minutes31.57 attemptsStandard Deviation 12.09
PlaceboChange in Serial Subtraction 7 Task PerformancePost-beverage 3-108 minutes33.90 attemptsStandard Deviation 12.11
Caffeinated PlaceboChange in Serial Subtraction 7 Task PerformancePost-beverage 3-108 minutes35.69 attemptsStandard Deviation 12.02
Caffeinated PlaceboChange in Serial Subtraction 7 Task PerformancePre-beverage-0 minutes27.90 attemptsStandard Deviation 10.13
Caffeinated PlaceboChange in Serial Subtraction 7 Task PerformancePost-beverage 2-68 minutes33.07 attemptsStandard Deviation 11.38
Caffeinated PlaceboChange in Serial Subtraction 7 Task PerformancePost-beverage 1- 30 minutes30.80 attemptsStandard Deviation 11.25
E+ShotsChange in Serial Subtraction 7 Task PerformancePost-beverage 3-108 minutes34.27 attemptsStandard Deviation 13.02
E+ShotsChange in Serial Subtraction 7 Task PerformancePost-beverage 1- 30 minutes32.60 attemptsStandard Deviation 10.99
E+ShotsChange in Serial Subtraction 7 Task PerformancePost-beverage 2-68 minutes33.47 attemptsStandard Deviation 11.6
E+ShotsChange in Serial Subtraction 7 Task PerformancePre-beverage-0 minutes28.77 attemptsStandard Deviation 11.04
Primary

Change in Serial Subtraction 7 Task Performance

Serial subtraction 7- Number correct

Time frame: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in Serial Subtraction 7 Task PerformancePre-beverage-0 minutes24.73 correct attemptsStandard Deviation 10.7
PlaceboChange in Serial Subtraction 7 Task PerformancePost -beverage 1-30 minutes27.83 correct attemptsStandard Deviation 10.7
PlaceboChange in Serial Subtraction 7 Task PerformancePost-beverage 2-68 minutes28.83 correct attemptsStandard Deviation 11.81
PlaceboChange in Serial Subtraction 7 Task PerformancePost-beverage 3-108 minutes30.43 correct attemptsStandard Deviation 11.43
Caffeinated PlaceboChange in Serial Subtraction 7 Task PerformancePost-beverage 3-108 minutes33.48 correct attemptsStandard Deviation 11.96
Caffeinated PlaceboChange in Serial Subtraction 7 Task PerformancePre-beverage-0 minutes26.17 correct attemptsStandard Deviation 10.3
Caffeinated PlaceboChange in Serial Subtraction 7 Task PerformancePost-beverage 2-68 minutes31.27 correct attemptsStandard Deviation 11.59
Caffeinated PlaceboChange in Serial Subtraction 7 Task PerformancePost -beverage 1-30 minutes29.03 correct attemptsStandard Deviation 10.81
E+ShotsChange in Serial Subtraction 7 Task PerformancePost-beverage 3-108 minutes31.60 correct attemptsStandard Deviation 13.15
E+ShotsChange in Serial Subtraction 7 Task PerformancePost -beverage 1-30 minutes30.20 correct attemptsStandard Deviation 10.95
E+ShotsChange in Serial Subtraction 7 Task PerformancePost-beverage 2-68 minutes30.41 correct attemptsStandard Deviation 11.84
E+ShotsChange in Serial Subtraction 7 Task PerformancePre-beverage-0 minutes27.00 correct attemptsStandard Deviation 11.23
Primary

Change in Serial Subtraction 7 Task Performance

Serial subtraction 7- Percentage correct

Time frame: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in Serial Subtraction 7 Task PerformancePre-beverage-0 minutes92.53 PercentageStandard Deviation 8.8
PlaceboChange in Serial Subtraction 7 Task PerformancePost-beverage 1- 30 minutes94.36 PercentageStandard Deviation 4.98
PlaceboChange in Serial Subtraction 7 Task PerformancePost-beverage 2-68 minutes92.92 PercentageStandard Deviation 8.42
PlaceboChange in Serial Subtraction 7 Task PerformancePost-beverage 3-108 minutes91.21 PercentageStandard Deviation 8.74
Caffeinated PlaceboChange in Serial Subtraction 7 Task PerformancePost-beverage 3-108 minutes93.17 PercentageStandard Deviation 6.07
Caffeinated PlaceboChange in Serial Subtraction 7 Task PerformancePre-beverage-0 minutes92.78 PercentageStandard Deviation 7.99
Caffeinated PlaceboChange in Serial Subtraction 7 Task PerformancePost-beverage 2-68 minutes93.80 PercentageStandard Deviation 6.6
Caffeinated PlaceboChange in Serial Subtraction 7 Task PerformancePost-beverage 1- 30 minutes93.59 PercentageStandard Deviation 8.08
E+ShotsChange in Serial Subtraction 7 Task PerformancePost-beverage 3-108 minutes90.60 PercentageStandard Deviation 9.18
E+ShotsChange in Serial Subtraction 7 Task PerformancePost-beverage 1- 30 minutes91.65 PercentageStandard Deviation 8.13
E+ShotsChange in Serial Subtraction 7 Task PerformancePost-beverage 2-68 minutes91.44 PercentageStandard Deviation 7.21
E+ShotsChange in Serial Subtraction 7 Task PerformancePre-beverage-0 minutes92.72 PercentageStandard Deviation 11.29
Primary

Change in State Mental Energy

State Mental Energy- scores range from 0 to 300 with higher scores indicating better outcome

Time frame: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in State Mental EnergyPre-beverage-0 minutes9.93 Score on a scaleStandard Deviation 6.01
PlaceboChange in State Mental EnergyPost-beverage 1- 30 minutes9.23 Score on a scaleStandard Deviation 6.3
PlaceboChange in State Mental EnergyPost-beverage 2-68 minutes9.90 Score on a scaleStandard Deviation 6.38
PlaceboChange in State Mental EnergyPost-beverage 3-108 minutes8.83 Score on a scaleStandard Deviation 5.42
Caffeinated PlaceboChange in State Mental EnergyPost-beverage 3-108 minutes9.73 Score on a scaleStandard Deviation 6.75
Caffeinated PlaceboChange in State Mental EnergyPre-beverage-0 minutes10.27 Score on a scaleStandard Deviation 6.26
Caffeinated PlaceboChange in State Mental EnergyPost-beverage 2-68 minutes9.17 Score on a scaleStandard Deviation 6.66
Caffeinated PlaceboChange in State Mental EnergyPost-beverage 1- 30 minutes8.70 Score on a scaleStandard Deviation 6.51
E+ShotsChange in State Mental EnergyPost-beverage 3-108 minutes10.16 Score on a scaleStandard Deviation 7.71
E+ShotsChange in State Mental EnergyPost-beverage 1- 30 minutes9.43 Score on a scaleStandard Deviation 7.23
E+ShotsChange in State Mental EnergyPost-beverage 2-68 minutes9.52 Score on a scaleStandard Deviation 7.16
E+ShotsChange in State Mental EnergyPre-beverage-0 minutes10.13 Score on a scaleStandard Deviation 7.39
Primary

Change in State Mental Fatigue

State mental fatigue- scores range from 0 to 300 with higher scores indicating worse outcome

Time frame: pre beverage-0 minutes, post beverage 1- 30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in State Mental FatiguePre beverage- 0 minutes13.27 Score on a scaleStandard Deviation 6.59
PlaceboChange in State Mental FatiguePost 1 beverage-30 minutes13.30 Score on a scaleStandard Deviation 6.2
PlaceboChange in State Mental FatiguePost 2 beverage- 60 minutes13.67 Score on a scaleStandard Deviation 6.77
PlaceboChange in State Mental FatiguePost 3 beverage- 108 minutes13.90 Score on a scaleStandard Deviation 7.39
Caffeinated PlaceboChange in State Mental FatiguePost 3 beverage- 108 minutes14.46 Score on a scaleStandard Deviation 7.12
Caffeinated PlaceboChange in State Mental FatiguePre beverage- 0 minutes13.40 Score on a scaleStandard Deviation 6.75
Caffeinated PlaceboChange in State Mental FatiguePost 2 beverage- 60 minutes14.07 Score on a scaleStandard Deviation 7.1
Caffeinated PlaceboChange in State Mental FatiguePost 1 beverage-30 minutes14.60 Score on a scaleStandard Deviation 7.12
E+ShotsChange in State Mental FatiguePost 3 beverage- 108 minutes16.44 Score on a scaleStandard Deviation 8.3
E+ShotsChange in State Mental FatiguePost 1 beverage-30 minutes15.60 Score on a scaleStandard Deviation 7.31
E+ShotsChange in State Mental FatiguePost 2 beverage- 60 minutes15.34 Score on a scaleStandard Deviation 7.49
E+ShotsChange in State Mental FatiguePre beverage- 0 minutes15.13 Score on a scaleStandard Deviation 6.58
Primary

Change in State Physical Energy

State Physical Energy- scores range from 0 to 300 with higher scores indicating better outcome

Time frame: pre-beverage-0 minutes, Post beverage 1-30 minutes, Post beverage 2-68 minutes, Post beverage 3 -108 minutes

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in State Physical EnergyPre beverage-0 minutes9.13 Score on a scaleStandard Deviation 5.87
PlaceboChange in State Physical EnergyPost 1 beverage-30 minutes8.43 Score on a scaleStandard Deviation 5.55
PlaceboChange in State Physical EnergyPost 2 beverage- 60 minutes8.63 Score on a scaleStandard Deviation 5.37
PlaceboChange in State Physical EnergyPost 3 beverage-108 minutes8.31 Score on a scaleStandard Deviation 5.55
Caffeinated PlaceboChange in State Physical EnergyPost 3 beverage-108 minutes8.37 Score on a scaleStandard Deviation 5.84
Caffeinated PlaceboChange in State Physical EnergyPre beverage-0 minutes9.50 Score on a scaleStandard Deviation 6.55
Caffeinated PlaceboChange in State Physical EnergyPost 2 beverage- 60 minutes8.62 Score on a scaleStandard Deviation 6.38
Caffeinated PlaceboChange in State Physical EnergyPost 1 beverage-30 minutes7.93 Score on a scaleStandard Deviation 6.11
E+ShotsChange in State Physical EnergyPost 3 beverage-108 minutes8.84 Score on a scaleStandard Deviation 6.58
E+ShotsChange in State Physical EnergyPost 1 beverage-30 minutes8.67 Score on a scaleStandard Deviation 6.23
E+ShotsChange in State Physical EnergyPost 2 beverage- 60 minutes8.83 Score on a scaleStandard Deviation 6.05
E+ShotsChange in State Physical EnergyPre beverage-0 minutes8.67 Score on a scaleStandard Deviation 6.14
Primary

Change in State Physical Fatigue

State physical fatigue- scores range from 0 to 300 with higher scores indicating worse outcome

Time frame: pre beverage-0, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3-108 minutes

ArmMeasureGroupValue (MEAN)Dispersion
PlaceboChange in State Physical FatiguePost 3 beverage- 108 minutes14.69 Score on a scaleStandard Deviation 6.89
PlaceboChange in State Physical FatiguePost 1 beverage-30 minutes14.23 Score on a scaleStandard Deviation 6.35
PlaceboChange in State Physical FatiguePost 2 beverage- 60 minutes14.57 Score on a scaleStandard Deviation 6.36
PlaceboChange in State Physical FatiguePre beverage-0 minutes13.87 Score on a scaleStandard Deviation 6.34
Caffeinated PlaceboChange in State Physical FatiguePost 2 beverage- 60 minutes15.31 Score on a scaleStandard Deviation 6.56
Caffeinated PlaceboChange in State Physical FatiguePost 3 beverage- 108 minutes15.31 Score on a scaleStandard Deviation 6.63
Caffeinated PlaceboChange in State Physical FatiguePre beverage-0 minutes14.63 Score on a scaleStandard Deviation 15.97
Caffeinated PlaceboChange in State Physical FatiguePost 1 beverage-30 minutes15.37 Score on a scaleStandard Deviation 6.56
E+ShotsChange in State Physical FatiguePost 3 beverage- 108 minutes16.92 Score on a scaleStandard Deviation 7.24
E+ShotsChange in State Physical FatiguePost 1 beverage-30 minutes16.40 Score on a scaleStandard Deviation 7.38
E+ShotsChange in State Physical FatiguePost 2 beverage- 60 minutes16.38 Score on a scaleStandard Deviation 7.27
E+ShotsChange in State Physical FatiguePre beverage-0 minutes16.40 Score on a scaleStandard Deviation 6.89

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026