Degenerative Osteoarthritis
Conditions
Brief summary
This study is being done to investigate the colonization rate(growth rate) of a particular type of low-virulence (does not typically cause infection) bacterium called Propionibacterium, more specifically P acnes, the same bacterium that is responsible for the majority of acne. Information affecting hip surgery is currently unknown.
Detailed description
This study is being done to investigate the colonization rate(growth rate) of a particular type of low-virulence (does not typically cause infection) bacterium called Propionibacterium. The most common bacterium of this family is P acnes, the same bacterium that is responsible for the majority of acne. There is increasing evidence that infection with P acnes and other Propionibacterium is a significant source of failure following certain orthopaedic shoulder procedures. However, information affecting hip surgery is currently unknown. Our personal experience leads us to believe that the numbers are actually quite high, since we are seeing an increased rate of Propionibacterium infection of hip replacement in the community. However, this type of study has never been done before, and therefore we simply do not know an accurate estimate for the average hip replacement patient's risk for Propionibacterium infection following hip replacement.
Interventions
Skin prep with Chlorohexidine wipes and BPO.
Sponsors
Colorado Joint Replacement
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Intervention model description
Group 1 - 4 %Chlorohexidine Wipe Group 2 - 4 % Chlorohexidine Wipe with 5% benzoyl peroxide (BPO) application
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients who are 18 to 79 85 years of age * CJR primary joint arthroplasty patients who are receiving care at Porter Adventist Hospital * CJR established primary knee or hip arthroplasty patients with a native hip joint (no replacement on the biopsy side) who volunteers as a research participant. * CJR patients without a previous arthroplasty procedure who have established care with our practice.
Exclusion criteria
* Previous history of hip infection * Current antibiotic use or antibiotic use within the past week * Previous history of Cutibacterium joint infection * Current immunodeficiency disease or disorder * Patients with active psoriatic disease or other focal inflammation over the hip * Previous total hip arthroplasty (bilateral for the case of TKA patients and healthy volunteers, contralateral for THA patients)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Propionibacterium colinization rate on hips of healthy subjects | Tissues samples taken at the time of surgery will be held for 14 days | The rate at which Propionibacterium could be isolated from the skin of healthy subjects at locations corresponding to both the direct anterior and posterior surgical approaches with and without intervention. |
Countries
United States
Contacts
Primary ContactRoseann Johnson, BS CCRP
Outcome results
None listed