Chronic Fatigue Syndrome, Intensive Care Unit, Muscle
Conditions
Keywords
Neuromuscular function
Brief summary
Chronic fatigue is the most common and debilitating symptom in intensive care unit (ICU) survivors. Indeed, it has been widely reported that patients who stayed in ICU for prolonged periods report a feeling of tiredness for months to years after ICU discharge. This chronic fatigue affects their quality of life by decreasing their capacity to perform simple tasks of daily life. The aim of the present project is to determine whether deteriorated neuromuscular function (i.e. increased fatigability) is involved in this feeling of chronic fatigue. Because the causes of this feeling are multi-dimensional, a large battery of tests will allow us to better understand the origin of chronic fatigue. A better knowledge of chronic fatigue etiology will allow to optimize rehabilitation treatments to decrease the apparition/persistence of chronic fatigue and in fine improve life quality.
Interventions
OTHERQuestionnaires
Quality of life Depression Physical pain Social provisions Quality of sleep
BIOLOGICALblood test
complete blood count and cytokine concentration
OTHERMaximal effort test
The maximal effort test with VO2max recordings will be assessed during the first visit to the laboratory.
DEVICEactigraphy
assessment of sleep quality
DEVICENeuromuscular evaluation
* The maximum isometric force produced by the knee extensors will be measured on the ergometer * the intensity of muscular electrical activity recorded by surface electromyography * Peripheral nerve stimulation * Transcranial magnetic stimulation * Magnetic resonance imaging (optional)
Sponsors
University of Saint-Etienne
Centre Hospitalier Universitaire de Saint Etienne
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Have been ventilated for at least 72 hours in the intensive care unit * IGS2 score (severity in resuscitation) \> 15 * FACIT-F (Functional Assessment of Chronic Illness Therapy-Fatigue) score ≥ 36 or a score ≤ 32 * intensive care unit discharge in ≥ 6 months and ≤ 5 years preceding the study * Approval received from a physician * Command of the French language
Exclusion criteria
* Taking neuroactive substances that can alter corticospinal excitability * Contraindication to the application of a magnetic field * Contraindication to the practice of Magnetic Resonance Imaging * Participant is pregnant * Patients with psychiatric disorders * Paraplegic and hemiplegic patients * Addictive disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| voluntary maximum force reduction | at 2 weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Neuromuscular function : Peripheral function | at visit 2 | Peripheral function by electrical nerve stimulation |
| Maximal oxygen uptake (VO2max) | at 2 weeks | measured by effort test |
| Neuromuscular function : cortical activity | at 2 weeks | Level of cortical activation and cortico-spinal excitability measured by transcranial magnetic stimulation |
| Quadriceps muscle volume (optional) | at 3 weeks | with Magnetic resonance imaging |
| muscle dysfunction (optional) | at 3 weeks | measured by a Phosphorus 31 Nuclear magnetic resonance test |
| quality of sleep | at baseline | measured by actigraphy |
Countries
France
Outcome results
None listed