Effectiveness of Bisacodyl Suppository Agent for Dose Reduction of Low Dose PEG

Simultaneous Combination of Bisacodyl Suppository Agent and 1L Polyethylene Glycol Plus Ascorbic Acid is Not Inferior and Comfortable Regimen Compared With 2L Polyethylene Glycol Plus Ascorbic Acid: A Randomized Controlled Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03849196

Enrollment

168

Registered

2019-02-21

Start date

2017-07-31

Completion date

2018-01-30

Last updated

2019-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bowel Preparation

Brief summary

Proper bowel cleansing before colonoscopy is an important factor to increase the detection rate of lesions. Low volume polyethylene glycol (PEG) plus ascorbic (PEG-Asc) has reduced the dosage of previous bowel preparation agent, but it still presents discomfort to patients. The aim of this study was to confirm the efficacy and convenience of volume reduction of PEG-Asc by adding bisacodyl suppository at the same day by compared with conventional 2L PEG-Asc.

Detailed description

Eligibility criteria: outpatients between the ages of 20 and 70 years, who were scheduled for colonoscopy between August 2017 and January 2018 Exclusion criteria: patients with a history of gastrointestinal tract surgery, inflammatory bowel disease, severe active colitis, underlying chronic kidney disease, or pregnancy. Outcome measures: the Boston Bowel Preparation Scale (BBPS)

Interventions

DRUG2L PEG-Asc

PEG-Asc powder

DRUGBisacodyl 10Mg Suppository

bisacodyl 10 mg suppository

DRUG1L PEG-Asc

PEG-Asc powder

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Intervention model description

prospective, randomized, and observer-blind study

Eligibility

Sex/Gender

ALL

Age

20 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* outpatients who were scheduled for colonoscopy between August 2017 and January 2018

Exclusion criteria

* History of gastrointestinal tract surgery * History of inflammatory bowel disease * History of severe active colitis * History of chronic kidney disease * pregnant woman.

Design outcomes

Primary

Measure	Time frame	Description
Boston Bowel Preparation Scale (BBPS).	1 hour	4-point scoring system (0-3) applied to each of the 3 colon segments (right colon including cecum and ascending colon, transverse colon including transverse colon, hepatic and splenic flexure, left colon including descending colon, sigmoid colon, and rectum)

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026