Antibiotic Resistant Infection, Prosthetic Joint Infection
Conditions
Keywords
bone and joint infection, Antibiotic pretreatment
Brief summary
One-step exchange arthroplasty is more and more used in the treatment of chronic infections, especially in patients at risk anesthetic. This strategy is not recommended in patients infected with multidrug-resistant organisms or difficult to treat because of a risk of bacterial persistence on the new implant. Antibiotic pretreatment by a narrow-spectrum molecule and for which resistance acquisition is difficult might be of interest to try to reduce the inoculum and avoid contamination of the new implant.
Interventions
OTHERAntibiotic pretreatment
a strategy with antibiotic pretreatment before one-step exchange arthroplasty in patients who bacteria responsible for the infection has been indentified (puncture, blood cultures,...)
Sponsors
Hospices Civils de Lyon
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Inclusion criteria
* patients having had a antibiotic pretreatment targeted before a one step exchange arthroplasty
Exclusion criteria
* none
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rate of Treatment Failure | Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption | Treatment failure is defined by local clinical and/or microbiological relapse; and/or need for additional surgery; death of septic origin |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| rate of use of this strategy | Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption | descriptions of patients managed with this strategy |
| rate of bacteria responsible for infection | Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption | bacterial epidemiology |
Countries
France
Outcome results
None listed