Knee Arthroscopic Surgery
Conditions
Brief summary
However, local anesthetic agents can produce analgesia for a limited time when used as a single injection. Bupivacaine is a local anesthetic that has an immediate action on pain by blocking peripheral afferents. However, as the ideal analgesic, the drug must cover the whole postoperative period (≥ 24 hours); therefore, bupivacaine is usually combined with many adjutants to provide long-lasting post-arthroscopy analgesia.
Detailed description
Intr-articular drug administration has gained popularity because of its simplicity and efficacy in achieving anesthesia for diagnostic and operative arthroscopy and for providing postoperative analgesia .although the knee joint has been examined most commonly, arthroscopy of other joints such as shoulder, ankle, wrist, metatarsophalangeal and temporomandibular joints is being increasingly used. Intra-articular installation of local anesthesia during arthroscopic procedures has been used by many orthopedic surgeons to provide pain relief after surgery.The aim of this study was to evaluate the analgesic efficacy of intra-articular dexamethasone versus fentanyl added as an adjuvant to bupivacaine in patients undergoing knee arthroscopic surgery
Interventions
DRUGGroup DB/Dexamethasone-Bupivacaine
The patient were received an intra-articular injection of 18ml bupivacaine 0.25% added to 8mg dexamethasone.
DRUGGroup FB /Fentanyl-Bupivacaine
The patient were received an intra-articular injection of 1 ug/kg fentanyl added to 18ml of 0.25% bupivacaine.
DRUGGroup PB/Placebo-Bupivacaine
Patients were received an intra-articular injection of 2ml isotonic saline added to 18ml of 0.25% bupivacaine.
Sponsors
Mansoura University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* American Society of Anesthesiologists physical status (ASA) I or II
Exclusion criteria
* Contraindication to spinal anesthesia. * Allergy to the study drugs. * Refusal of the patients.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Duration of postoperative analgesia | for 24 hour after surgery | Time to the first request of pethidine in minutes within the first 24 hours postoperatively |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Total analgesic requirement | for 24 hour after surgery | Total analgesic requirement of pethidine will be recorded during the first 24 hours following surgery |
| Mean arterial blood pressure | At 1,2,4,6,8,12,18 and 24 hours postoperatively. | Mean arterial blood pressure measured in mm Hg and assessed at 1,2,4,6,8,12,18 and 24 hours following the discharge of the patient from the operating theatre. |
| Heart rate | At 1,2,4,6,8,12,18 and 24 hours postoperatively. | Heart rate will be measured in beats/minute and assessed at 1,2,4,6,8,12,18 and 24 hours following the discharge of the patient from the operating theatre. |
| Pain score | measured at 1,2,4,6,8,12,18 and 24 hours postoperatively. | Measured with visual analogue score(VAS):0=no pain and 100=worst imaginable pain measured at 1,2,4,6,8,12,18 and 24 hours |
| Patients' satisfaction | for 24 hour after surgery | satisfaction score from 1 to 4; as 4=Excellent ,3=good ,2=satisfactory and 1=poor will be measured after 24 hours. |
Countries
Egypt
Outcome results
None listed