Endothelial Dysfunction, Sepsis, Septic Shock
Conditions
Keywords
perfused boundary region, PBR, Sepsis, endothelial glycocalyx, ICU
Brief summary
The aim of this observative, prospective study is to evaluate if and to what extent glycocalyx damage/microcirculation data at admission in the ICU as well as during ICU stay can be predictive of mortality and clinical course in patients presenting with the suspicion of sepsis/septic shock. Therefore, the enrollment of ca 100 ICU patients is planned.
Interventions
OTHEREndothelial Glycocalyx
Non-invasive assessment of endothelial glycocalyx dimensions.
Sponsors
University Hospital Muenster
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* ICU patients admitted to the ICU with the clinican suspicion of sepsis/septic shock.
Exclusion criteria
* Underage persons, pregnant women, patients with inflammation or trauma of sublingual mucosa.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Predictive value of glycocalyx thickness regarding clinical course. | Hospital stay, an expected time of 4 weeks. | Glycocalyx thickness measured with the use of GlycoCheck System (Perfused Boundary Region - PBR, in µm). Clinical course will be estimated with the use of e.g. Sequential Organ Failure Assessment (SOFA) score (in points). |
| Predictive value of glycocalyx thickness regarding mortality. | Hospital stay, an expected time of 4 weeks. | Glycocalyx thickness measured with the use of GlycoCheck System (Perfused Boundary Region - PBR, in µm). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation of glycocalyx thickness with disease severity. | Hospital stay, an expected time of 4 weeks. | Glycocalyx thickness will be measured with the use of GlycoCheck System (Perfused Boundary Region - PBR, in μm). Disease severity will be assessed with ICU scores (e.g. SOFA Score - pts) |
Countries
Germany
Outcome results
None listed